| Gene Information | |
|---|---|
| Gene Name | DPP6 |
| Organism | Homo sapiens (Human) |
| Gene Length | 865 |
| Protein Names | Dipeptidyl aminopeptidase-like protein 6 (DPPX) (Dipeptidyl aminopeptidase-related protein) (Dipeptidyl peptidase 6) (Dipeptidyl peptidase IV-like protein) (Dipeptidyl peptidase VI) (DPP VI) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000130226 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | P42658 |
| Gene Card | DPP6 |
| Uniprot ID | P42658 |
| Pfam | PF00930; PF00326 |
| In ASD | no |
| Allosteric Prediction | yes (0.120826845) |
| Ortholog in Animals | Alpaca_ DPP6 ( ortholog_one2one ) Dog_ DPP6 ( ortholog_one2one ) GuineaPig_ DPP6 ( ortholog_one2one ) Macaque_ DPP6 ( ortholog_one2one ) Mouse_ Dpp6 ( ortholog_one2one ) Pig_ DPP6 ( ortholog_one2one ) Rat_ Dpp6 ( ortholog_one2one ) Rabbit_ DPP6 ( ortholog_one2one ) |
| Ohnologs | FAP, DPP10, DPP4 |
| Paralogs | APEH, FAP, DPP8, DPP9, DPP4, DPP10 |
| Tissue | cerebral.cortex, endometrium |
| Tissue Specificity | Expressed predominantly in brain. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 1XFD (X-ray 3.00A ) 7E87 (EM 3.40A ) 7E89 (EM 4.00A ) 7E8B (EM 4.20A ) 7E8E (EM 3.90A ) 7E8G (EM 4.50A ) 7E8H (EM 4.50A ) |
| DBSNP | rs786205143 rs3734960 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:18364354, ECO:0000269|PubMed:19441798}; Single-pass type II membrane protein {ECO:0000305}. |
| Mouse PG classification | LPG |
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