Gene Information
Gene NameDPP4
OrganismHomo sapiens (Human)
Gene Length766
Protein NamesDipeptidyl peptidase 4 (EC 3.4.14.5) (ADABP) (Adenosine deaminase complexing protein 2) (ADCP-2) (Dipeptidyl peptidase IV) (DPP IV) (T-cell activation antigen CD26) (TP103) (CD antigen CD26) [Cleaved into: Dipeptidyl peptidase 4 membrane form (Dipeptidyl peptidase IV membrane form); Dipeptidyl peptidase 4 soluble form (Dipeptidyl peptidase IV soluble form)]
Target Namedipeptidyl peptidase 4
Target TypeSuccessful target
Gene Age1488 ( ENSG00000197635 )
Evolutionary StageEuk+Bac
AlphaFoldDBP27487
Gene CardDPP4
Uniprot IDP27487
PfamPF00930; PF00326
In ASDyes
Allosteric Predictionyes (1.449221048)
Ortholog in AnimalsAlpaca_ DPP4 ( ortholog_one2one )
Dog_ DPP4 ( ortholog_one2one )
GuineaPig_ DPP4 ( ortholog_one2one )
Macaque_ DPP4 ( ortholog_one2one )
Mouse_ Dpp4 ( ortholog_one2one )
Pig_ DPP4 ( ortholog_one2one )
Rat_ Dpp4 ( ortholog_many2many )
OhnologsDPP6
ParalogsAPEH, FAP, DPP8, DPP6, DPP9, DPP10
TissueNA
Tissue SpecificityExpressed specifically in lymphatic vessels but not in blood vessels in the skin, small intestine, esophagus, ovary, breast and prostate glands. Not detected in lymphatic vessels in the lung, kidney, uterus, liver and stomach (at protein level). Expressed in the poorly differentiated crypt cells of the small intestine as well as in the mature villous cells. Expressed at very low levels in the colon. {ECO:0000269|PubMed:1677636, ECO:0000269|PubMed:18708048}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1J2E  (X-ray  2.60A  )  1N1M  (X-ray  2.50A  )  1NU6  (X-ray  2.10A  )  1NU8  (X-ray  2.50A  )  1PFQ  (X-ray  1.90A  )  1R9M  (X-ray  2.10A  )  1R9N  (X-ray  2.30A  )  1RWQ  (X-ray  2.20A  )  1TK3  (X-ray  2.00A  )  1TKR  (X-ray  2.70A  )  1U8E  (X-ray  2.20A  )  1W1I  (X-ray  3.03A  )  1WCY  (X-ray  2.20A  )  1X70  (X-ray  2.10A  )  2AJL  (X-ray  2.50A  )  2BGN  (X-ray  3.15A  )  2BGR  (X-ray  2.00A  )  2BUB  (X-ray  2.66A  )  2FJP  (X-ray  2.40A  )  2G5P  (X-ray  2.40A  )  2G5T  (X-ray  2.30A  )  2G63  (X-ray  2.00A  )  2HHA  (X-ray  2.35A  )  2I03  (X-ray  2.40A  )  2I78  (X-ray  2.50A  )  2IIT  (X-ray  2.35A  )  2IIV  (X-ray  2.15A  )  2JID  (X-ray  2.80A  )  2OAG  (X-ray  2.30A  )  2OGZ  (X-ray  2.10A  )  2OLE  (X-ray  2.40A  )  2ONC  (X-ray  2.55A  )  2OPH  (X-ray  2.40A  )  2OQI  (X-ray  2.80A  )  2OQV  (X-ray  2.80A  )  2P8S  (X-ray  2.20A  )  2QJR  (X-ray  2.20A  )  2QKY  (X-ray  3.10A  )  2QOE  (X-ray  2.30A  )  2QT9  (X-ray  2.10A  )  2QTB  (X-ray  2.25A  )  2RGU  (X-ray  2.60A  )  2RIP  (X-ray  2.90A  )  3BJM  (X-ray  2.35A  )  3C43  (X-ray  2.30A  )  3C45  (X-ray  2.05A  )  3CCB  (X-ray  2.49A  )  3CCC  (X-ray  2.71A  )  3D4L  (X-ray  2.00A  )  3EIO  (X-ray  2.00A  )  3F8S  (X-ray  2.43A  )  3G0B  (X-ray  2.25A  )  3G0C  (X-ray  2.69A  )  3G0D  (X-ray  2.39A  )  3G0G  (X-ray  2.45A  )  3H0C  (X-ray  2.66A  )  3HAB  (X-ray  2.10A  )  3HAC  (X-ray  2.00A  )  3KWF  (X-ray  2.40A  )  3KWJ  (X-ray  2.80A  )  3NOX  (X-ray  2.34A  )  3O95  (X-ray  2.85A  )  3O9V  (X-ray  2.75A  )  3OC0  (X-ray  2.70A  )  3OPM  (X-ray  2.72A  )  3Q0T  (X-ray  2.40A  )  3Q8W  (X-ray  3.64A  )  3QBJ  (X-ray  2.21A  )  3SWW  (X-ray  2.00A  )  3SX4  (X-ray  2.60A  )  3VJK  (X-ray  2.49A  )  3VJL  (X-ray  2.39A  )  3VJM  (X-ray  2.10A  )  3W2T  (X-ray  2.36A  )  3WQH  (X-ray  2.85A  )  4A5S  (X-ray  1.62A  )  4DSA  (X-ray  3.25A  )  4DSZ  (X-ray  3.20A  )  4DTC  (X-ray  3.00A  )  4G1F  (X-ray  2.90A  )  4J3J  (X-ray  3.20A  )  4JH0  (X-ray  2.35A  )  4KR0  (X-ray  2.70A  )  4L72  (X-ray  3.00A  )  4LKO  (X-ray  2.43A  )  4N8D  (X-ray  1.65A  )  4N8E  (X-ray  2.30A  )  4PNZ  (X-ray  1.90A  )  4PV7  (X-ray  3.24A  )  4QZV  (X-ray  2.59A  )  5I7U  (X-ray  1.95A  )  5ISM  (X-ray  2.00A  )  5J3J  (X-ray  2.75A  )  5KBY  (X-ray  2.24A  )  5T4B  (X-ray  1.76A  )  5T4E  (X-ray  1.77A  )  5T4F  (X-ray  1.90A  )  5T4H  (X-ray  2.61A  )  5Y7H  (X-ray  3.00A  )  5Y7J  (X-ray  2.52A  )  5Y7K  (X-ray  2.51A  )  5ZID  (X-ray  3.00A  )  6B1E  (X-ray  1.77A  )  6B1O  (X-ray  1.91A  ) 
DBSNP rs56179129 
Subcellular location [CC][Dipeptidyl peptidase 4 soluble form]: Secreted {ECO:0000269|PubMed:10951221, ECO:0000269|PubMed:16254193}. Note=Detected in the serum and the seminal fluid. {ECO:0000269|PubMed:10951221, ECO:0000269|PubMed:16254193}.;
Cell membrane {ECO:0000269|PubMed:10900005, ECO:0000269|PubMed:11772392, ECO:0000305|PubMed:8101391};
Single-pass type II membrane protein. Apical cell membrane {ECO:0000269|PubMed:11773049};
Single-pass type II membrane protein. Cell projection, invadopodium membrane {ECO:0000269|PubMed:16651416};
Single-pass type II membrane protein. Cell projection, lamellipodium membrane {ECO:0000269|PubMed:16651416};
Single-pass type II membrane protein. Cell junction {ECO:0000269|PubMed:11772392}. Membrane raft {ECO:0000269|PubMed:17287217}. Note=Translocated to the apical membrane through the concerted action of N- and O-Glycans and its association with lipid microdomains containing cholesterol and sphingolipids (PubMed:11773049). Redistributed to membrane rafts in T-cell in an interleukin-12-dependent activation (PubMed:12676959). Its interaction with CAV1 is necessary for its translocation to membrane rafts (PubMed:17287217). Colocalized with PTPRC in membrane rafts (PubMed:12676959). Colocalized with FAP in invadopodia and lamellipodia of migratory activated endothelial cells in collagenous matrix. Colocalized with FAP on endothelial cells of capillary-like microvessels but not large vessels within invasive breast ductal carcinoma (PubMed:16651416). Colocalized with ADA at the cell junction in lymphocyte-epithelial cell adhesion (PubMed:11772392). Colocalized with IGF2R in internalized cytoplasmic vesicles adjacent to the cell surface (PubMed:10900005). {ECO:0000269|PubMed:10900005, ECO:0000269|PubMed:11772392, ECO:0000269|PubMed:11773049, ECO:0000269|PubMed:12676959, ECO:0000269|PubMed:16651416, ECO:0000269|PubMed:17287217}.
Mouse PG classificationNA
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