| Gene Information | |
|---|---|
| Gene Name | FOXO4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 505 |
| Protein Names | Forkhead box protein O4 (Fork head domain transcription factor AFX1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000184481 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | P98177 |
| Gene Card | FOXO4 |
| Uniprot ID | P98177 |
| Pfam | PF00250; PF16676 |
| In ASD | no |
| Allosteric Prediction | yes (0.836871229) |
| Ortholog in Animals | Alpaca_ FOXO4 ( ortholog_one2one ) Dog_ FOXO4 ( ortholog_one2one ) GuineaPig_ FOXO4 ( ortholog_one2one ) Macaque_ FOXO4 ( ortholog_one2one ) Mouse_ Foxo4 ( ortholog_one2one ) Pig_ FOXO4 ( ortholog_one2one ) Rat_ Foxo4 ( ortholog_one2one ) Rabbit_ FOXO4 ( ortholog_one2one ) |
| Ohnologs | FOXO3, FOXO1, FOXO6 |
| Paralogs | FOXH1, FOXL3, FOXK2, FOXM1, FOXQ1, FOXP3, FOXB2, FOXR1, FOXI2, FOXD2, FOXA2, FOXJ2, FOXD4L1, FOXD4L3, FOXD4L6, FOXD4, FOXD4L5, FOXD4L4, FOXS1, FOXC1, FOXL1, FOXP1, FOXC2, FOXF1, FOXB1, FOXK1, FOXA1, FOXL2, FOXE1, FOXR2, FOXE3, FOXO3B, FOXO3, FOXJ3, FOXD1, FOXD3, FOXO1, FOXI3, FOXJ1, FOXO6, FOXA3, FOXN1 |
| Tissue | placenta |
| Tissue Specificity | Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Isoform zeta is most abundant in the liver, kidney, and pancreas. |
| Pharmacological Animal Models | 0.000730(Chimpanzee);0.035650(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 1E17 (NMR - ) 3L2C (X-ray 1.87A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm. Nucleus. Note=When phosphorylated, translocated from nucleus to cytoplasm. Dephosphorylation triggers nuclear translocation. Monoubiquitination increases nuclear localization. When deubiquitinated, translocated from nucleus to cytoplasm. |
| Mouse PG classification | NA |
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