| Gene Information | |
|---|---|
| Gene Name | PTPRE |
| Organism | Homo sapiens (Human) |
| Gene Length | 700 |
| Protein Names | Receptor-type tyrosine-protein phosphatase epsilon (Protein-tyrosine phosphatase epsilon) (R-PTP-epsilon) (EC 3.1.3.48) |
| Target Name | receptor-type tyrosine-protein phosphatase epsilon |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000132334 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P23469 |
| Gene Card | PTPRE |
| Uniprot ID | P23469 |
| Pfam | PF00102 |
| In ASD | no |
| Allosteric Prediction | yes (0.236432903) |
| Ortholog in Animals | Alpaca_ PTPRE ( ortholog_one2one ) Dog_ PTPRE ( ortholog_one2one ) GuineaPig_ PTPRE ( ortholog_one2one ) Macaque_ PTPRE ( ortholog_one2one ) Mouse_ Ptpre ( ortholog_one2one ) Pig_ PTPRE ( ortholog_one2one ) Rat_ Ptpre ( ortholog_one2one ) Rabbit_ PTPRE ( ortholog_one2one ) |
| Ohnologs | PTPRA |
| Paralogs | PTPN12, PTPRC, PTPN6, PTPN18, PTPN7, PTPN1, PTPN13, PTPRF, PTPRK, PTPRB, PTPRA, PTPN22, PTPRG, PTPRR, PTPN5, PTPN23, PTPRZ1, PTPN9, PTPN4, PTPRT, PTPRS, PTPRD, PTPN2, PTPRO, PTPRJ, PTPRM, PTPN11, PTPN20, PTPRU, PTPN14, PTPN3, PTPRN, PTPRN2, PTPRH, PTPN21 |
| Tissue | NA |
| Tissue Specificity | Expressed in giant cell tumor (osteoclastoma rich in multinucleated osteoclastic cells). {ECO:0000269|PubMed:8610169}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2JJD (X-ray 3.20A ) 6D3F (X-ray 2.27A ) 6D4D (X-ray 1.76A ) 6D4F (X-ray 1.91A ) |
| DBSNP | NA |
| Subcellular location [CC] | [Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Cytoplasm. Note=Predominantly cytoplasmic. A small fraction is also associated with nucleus and membrane. Insulin induces translocation to the membrane (By similarity). {ECO:0000250}.; [Isoform 3]: Cytoplasm. |
| Mouse PG classification | NA |
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