| Gene Information | |
|---|---|
| Gene Name | PI4K2B |
| Organism | Homo sapiens (Human) |
| Gene Length | 481 |
| Protein Names | Phosphatidylinositol 4-kinase type 2-beta (EC 2.7.1.67) (Phosphatidylinositol 4-kinase type II-beta) (PI4KII-BETA) |
| Target Name | phosphatidylinositol 4-kinase type 2-beta |
| Target Type | NA |
| Gene Age | 1292 ( ENSG00000038210 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | Q8TCG2 |
| Gene Card | PI4K2B |
| Uniprot ID | Q8TCG2 |
| Pfam | PF00454 |
| In ASD | no |
| Allosteric Prediction | yes (0.200377314) |
| Ortholog in Animals | Alpaca_ PI4K2B ( ortholog_one2one ) Dog_ PI4K2B ( ortholog_one2one ) GuineaPig_ PI4K2B ( ortholog_one2one ) Macaque_ PI4K2B ( ortholog_one2one ) Mouse_ Pi4k2b ( ortholog_one2one ) Pig_ PI4K2B ( ortholog_one2one ) Rat_ Pi4k2b ( ortholog_one2one ) Rabbit_ PI4K2B ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | PI4K2A |
| Tissue | NA |
| Tissue Specificity | Widely expressed. {ECO:0000269|PubMed:11923287}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4WTV (X-ray 1.90A ) |
| DBSNP | rs313549 |
| Subcellular location [CC] | Cytoplasm, cytosol {ECO:0000269|PubMed:12324459}. Golgi apparatus membrane {ECO:0000269|PubMed:11923287, ECO:0000269|PubMed:12324459}; Peripheral membrane protein {ECO:0000269|PubMed:12324459}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:12324459}. Cell membrane {ECO:0000269|PubMed:11923287, ECO:0000269|PubMed:12324459}. Early endosome membrane {ECO:0000269|PubMed:11923287}. Note=Mainly cytosolic, association with membranes of the Golgi, endoplasmic and plasma membrane is stimulated by active RAC1 (PubMed:12324459). Association with early endosomes has not been confirmed (PubMed:11923287, PubMed:12324459). {ECO:0000269|PubMed:11923287, ECO:0000269|PubMed:12324459}. |
| Mouse PG classification | NA |
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