| Gene Information | |
|---|---|
| Gene Name | DPDE3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 809 |
| Protein Names | cAMP-specific 3',5'-cyclic phosphodiesterase 4D (EC 3.1.4.53) (DPDE3) (PDE43) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q08499 |
| Gene Card | PDE4D |
| Uniprot ID | Q08499 |
| Pfam | PF18100; PF00233 |
| In ASD | yes |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed in colonic epithelial cells (at protein level). Widespread; most abundant in skeletal muscle. {ECO:0000269|PubMed:12834813, ECO:0000269|PubMed:17244609}.; [Isoform 6]: Detected in brain. {ECO:0000269|PubMed:12834813, ECO:0000269|PubMed:17519386}.; [Isoform 8]: Detected in brain, placenta, lung and kidney. {ECO:0000269|PubMed:12834813}.; [Isoform 7]: Detected in heart and skeletal muscle. {ECO:0000269|PubMed:12834813}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1E9K (NMR - ) 1MKD (X-ray 2.90A ) 1OYN (X-ray 2.00A ) 1PTW (X-ray 2.30A ) 1Q9M (X-ray 2.30A ) 1TB7 (X-ray 1.63A ) 1TBB (X-ray 1.60A ) 1XOM (X-ray 1.55A ) 1XON (X-ray 1.72A ) 1XOQ (X-ray 1.83A ) 1XOR (X-ray 1.54A ) 1Y2B (X-ray 1.40A ) 1Y2C (X-ray 1.67A ) 1Y2D (X-ray 1.70A ) 1Y2E (X-ray 2.10A ) 1Y2K (X-ray 1.36A ) 1ZKN (X-ray 2.10A ) 2FM0 (X-ray 2.00A ) 2FM5 (X-ray 2.03A ) 2PW3 (X-ray 1.56A ) 2QYN (X-ray 1.57A ) 3G4G (X-ray 2.30A ) 3G4I (X-ray 1.90A ) 3G4K (X-ray 1.95A ) 3G4L (X-ray 2.50A ) 3G58 (X-ray 2.05A ) 3IAD (X-ray 2.65A ) 3IAK (X-ray 2.80A ) 3K4S (X-ray 2.05A ) 3SL3 (X-ray 2.10A ) 3SL4 (X-ray 1.90A ) 3SL5 (X-ray 2.65A ) 3SL6 (X-ray 2.44A ) 3SL8 (X-ray 2.60A ) 3V9B (X-ray 2.10A ) 4OGB (X-ray 2.03A ) 4W1O (X-ray 2.20A ) 4WCU (X-ray 2.35A ) 5K1I (X-ray 2.61A ) 5K32 (X-ray 1.99A ) 5LBO (X-ray 2.25A ) 5TKB (X-ray 2.16A ) 5WH5 (X-ray 1.80A ) 5WH6 (X-ray 1.60A ) 5WQA (X-ray 2.30A ) 6AKR (X-ray 2.33A ) 6BOJ (X-ray 1.70A ) 6F6U (X-ray 1.83A ) 6F8R (X-ray 1.83A ) 6F8T (X-ray 1.80A ) 6F8U (X-ray 2.10A ) 6F8V (X-ray 1.85A ) 6F8W (X-ray 1.60A ) 6F8X (X-ray 1.95A ) 6FDC (X-ray 1.45A ) 6FDI (X-ray 1.90A ) 6FE7 (X-ray 2.00A ) 6FEB (X-ray 1.93A ) 6FET (X-ray 1.88A ) 6FT0 (X-ray 2.10A ) 6FTA (X-ray 2.34A ) 6FTW (X-ray 2.16A ) 6FW3 (X-ray 1.78A ) 6HWO (X-ray 1.99A ) 6IAG (X-ray 2.00A ) 6IBF (X-ray 2.31A ) 6IM6 (X-ray 1.70A ) 6IMB (X-ray 1.55A ) 6IMD (X-ray 1.50A ) 6IMI (X-ray 1.46A ) 6IMO (X-ray 1.55A ) 6IMR (X-ray 1.50A ) 6IMT (X-ray 1.48A ) 6IND (X-ray 1.87A ) 6INK (X-ray 1.70A ) 6INM (X-ray 2.00A ) 6KJZ (X-ray 2.20A ) 6KK0 (X-ray 2.20A ) 6LRM (X-ray 1.45A ) 6NJH (X-ray 2.15A ) 6NJI (X-ray 2.45A ) 6NJJ (X-ray 2.30A ) 6RCW (X-ray 2.08A ) 6ZBA (X-ray 1.60A ) 7A8Q (X-ray 2.24A ) 7A9V (X-ray 2.17A ) 7AAG (X-ray 1.79A ) 7AB9 (X-ray 2.19A ) 7ABD (X-ray 2.41A ) 7ABE (X-ray 1.83A ) 7ABJ (X-ray 2.11A ) 7AY6 (X-ray 1.66A ) 7B9H (X-ray 1.50A ) 7CBJ (X-ray 1.50A ) 7CBQ (X-ray 1.59A ) 7F2K (X-ray 2.10A ) 7F2L (X-ray 2.10A ) 7F2M (X-ray 2.20A ) 7W4X (X-ray 2.20A ) 7W4Y (X-ray 2.10A ) 7XBB (X-ray 2.10A ) |
| DBSNP | rs397514466 rs397514464 rs397514465 rs397514468 rs397515433 rs397514467 rs397514469 rs587777188 |
| Subcellular location [CC] | Apical cell membrane {ECO:0000269|PubMed:14500724}. Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Note=Found in the soluble fraction, associated with membranes, and associated with the cytoskeleton and the centrosome (By similarity). Colocalized with SHANK2 to the apical membrane of colonic crypt cells. {ECO:0000250}. |
| Mouse PG classification | NA |
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