| Gene Information | |
|---|---|
| Gene Name | DPC4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 552 |
| Protein Names | Mothers against decapentaplegic homolog 4 (MAD homolog 4) (Mothers against DPP homolog 4) (Deletion target in pancreatic carcinoma 4) (SMAD family member 4) (SMAD 4) (Smad4) (hSMAD4) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q13485 |
| Gene Card | SMAD4 |
| Uniprot ID | Q13485 |
| Pfam | PF03165; PF03166 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.035088(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1DD1 (X-ray 2.62A ) 1G88 (X-ray 3.00A ) 1MR1 (X-ray 2.85A ) 1U7F (X-ray 2.60A ) 1U7V (X-ray 2.70A ) 1YGS (X-ray 2.10A ) 5C4V (X-ray 2.60A ) 5MEY (X-ray 2.05A ) 5MEZ (X-ray 2.98A ) 5MF0 (X-ray 3.03A ) 5UWU (X-ray 2.24A ) 6YIC (X-ray 1.60A ) |
| DBSNP | rs281875323 rs1555685186 rs281875324 rs1057519739 rs121912581 rs80338963 rs377767347 rs121912580 rs121912578 rs281875320 rs281875321 rs281875322 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:15799969, ECO:0000269|PubMed:17327236}. Nucleus {ECO:0000269|PubMed:15799969}. Note=Cytoplasmic in the absence of ligand. Migrates to the nucleus when complexed with R-SMAD (PubMed:15799969). PDPK1 prevents its nuclear translocation in response to TGF-beta (PubMed:17327236). {ECO:0000269|PubMed:15799969, ECO:0000269|PubMed:17327236}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |