| Gene Information | |
|---|---|
| Gene Name | DOK5 |
| Organism | Homo sapiens (Human) |
| Gene Length | 306 |
| Protein Names | Docking protein 5 (Downstream of tyrosine kinase 5) (Insulin receptor substrate 6) (IRS-6) (IRS6) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000101134 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9P104 |
| Gene Card | DOK5 |
| Uniprot ID | Q9P104 |
| Pfam | PF02174 |
| In ASD | no |
| Allosteric Prediction | no (-0.713132148) |
| Ortholog in Animals | Alpaca_ DOK5 ( ortholog_one2one ) Dog_ DOK5 ( ortholog_one2one ) GuineaPig_ DOK5 ( ortholog_one2one ) Macaque_ DOK5 ( ortholog_one2one ) Mouse_ Dok5 ( ortholog_one2one ) Pig_ DOK5 ( ortholog_one2one ) Rat_ Dok5 ( ortholog_one2one ) Rabbit_ DOK5 ( ortholog_one2one ) |
| Ohnologs | DOK4, DOK6 |
| Paralogs | DOK6, DOK4, DOK2, FRS3, FRS2, DOK1, DOK3 |
| Tissue | heart, ovary |
| Tissue Specificity | Highest expression in skeletal muscle, lower in brain, heart and kidney. Also detected in activated peripheral blood T-lymphocytes. {ECO:0000269|PubMed:12595900, ECO:0000269|PubMed:12730241}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1J0W (X-ray 2.50A ) |
| DBSNP | NA |
| Subcellular location [CC] | NA |
| Mouse PG classification | NA |
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