| Gene Information | |
|---|---|
| Gene Name | DOK4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 326 |
| Protein Names | Docking protein 4 (Downstream of tyrosine kinase 4) (Insulin receptor substrate 5) (IRS-5) (IRS5) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 886 ( ENSG00000125170 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q8TEW6 |
| Gene Card | DOK4 |
| Uniprot ID | Q8TEW6 |
| Pfam | PF02174 |
| In ASD | no |
| Allosteric Prediction | no (-0.623557974) |
| Ortholog in Animals | Alpaca_ DOK4 ( ortholog_one2one ) Dog_ DOK4 ( ortholog_one2one ) GuineaPig_ DOK4 ( ortholog_one2one ) Macaque_ DOK4 ( ortholog_one2one ) Mouse_ Dok4 ( ortholog_one2one ) Pig_ DOK4 ( ortholog_one2one ) Rat_ Dok4 ( ortholog_one2one ) Rabbit_ DOK4 ( ortholog_one2one ) |
| Ohnologs | DOK5, DOK6 |
| Paralogs | DOK6, DOK2, FRS3, FRS2, DOK1, DOK3, DOK5 |
| Tissue | NA |
| Tissue Specificity | Widely expressed. High expression in skeletal muscle, heart, kidney and liver. Weaker expression in spleen, lung and small intestine, brain, heart and. Expressed in both resting and activated peripheral blood T-cells. {ECO:0000269|PubMed:12595900, ECO:0000269|PubMed:12730241}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | NA |
| Mouse PG classification | NA |
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