| Gene Information | |
|---|---|
| Gene Name | DOK1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 481 |
| Protein Names | Docking protein 1 (Downstream of tyrosine kinase 1) (p62(dok)) (pp62) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 886 ( ENSG00000115325 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q99704 |
| Gene Card | DOK1 |
| Uniprot ID | Q99704 |
| Pfam | PF02174; PF00169 |
| In ASD | no |
| Allosteric Prediction | no (-0.391216041) |
| Ortholog in Animals | Alpaca_ DOK1 ( ortholog_one2one ) Dog_ DOK1 ( ortholog_one2one ) GuineaPig_ DOK1 ( ortholog_one2one ) Macaque_ DOK1 ( ortholog_one2one ) Mouse_ Dok1 ( ortholog_one2one ) Pig_ DOK1 ( ortholog_one2one ) Rat_ Dok1 ( ortholog_one2one ) Rabbit_ DOK1 ( ortholog_one2one ) |
| Ohnologs | DOK3, DOK2 |
| Paralogs | DOK6, DOK4, DOK2, FRS3, FRS2, DOK3, DOK5 |
| Tissue | NA |
| Tissue Specificity | Expressed in pancreas, heart, leukocyte and spleen. Expressed in both resting and activated peripheral blood T-cells. Expressed in breast cancer. {ECO:0000269|PubMed:12595900}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002808(Rat);0.023077(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 2V76 (X-ray 1.60A ) |
| DBSNP | NA |
| Subcellular location [CC] | [Isoform 1]: Cytoplasm. Nucleus.; [Isoform 3]: Cytoplasm, perinuclear region. |
| Mouse PG classification | NA |
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