| Gene Information | |
|---|---|
| Gene Name | DOCK4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1966 |
| Protein Names | Dedicator of cytokinesis protein 4 |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000128512 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q8N1I0 |
| Gene Card | DOCK4 |
| Uniprot ID | Q8N1I0 |
| Pfam | PF06920; PF20422; PF20421; PF14429; PF16172; PF07653 |
| In ASD | no |
| Allosteric Prediction | yes (0.120697088) |
| Ortholog in Animals | Alpaca_ DOCK4 ( ortholog_one2one ) Dog_ DOCK4 ( ortholog_one2one ) GuineaPig_ DOCK4 ( ortholog_one2one ) Macaque_ DOCK4 ( ortholog_one2one ) Mouse_ Dock4 ( ortholog_one2one ) Pig_ DOCK4 ( ortholog_one2one ) Rat_ Dock4 ( ortholog_one2one ) Rabbit_ DOCK4 ( ortholog_one2one ) |
| Ohnologs | DOCK3, DOCK2 |
| Paralogs | DOCK6, DOCK9, DOCK8, DOCK2, DOCK1, DOCK10, DOCK3, DOCK11, DOCK5, DOCK7 |
| Tissue | brain.meninx, caudate.nucleus, diencephalon, globus.pallidus, hippocampus, middle.frontal.gyrus, middle.temporal.gyrus, occipital.cortex, occipital.lobe, olfactory.apparatus, parietal.lobe, putamen, thalamus |
| Tissue Specificity | Widely expressed at low level. Highly expressed in skeletal muscle, prostate and ovary. {ECO:0000269|PubMed:12628187}.; [Isoform 2]: May be specifically expressed in the brain and eye. {ECO:0000269|PubMed:16464467}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.008759(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs1396518456 rs12705801 rs2074130 rs3757650 rs3757651 rs150569245 rs10281942 rs369715294 rs12705795 rs199706346 rs34597439 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:12628187}. Cell projection {ECO:0000269|PubMed:20679435}. Cytoplasm, cytosol {ECO:0000305|PubMed:20679435}. Note=Colocalizes with EPHA2, RHOG and CTTN/cortactin at the tip of protrusions in migrating cells. {ECO:0000269|PubMed:20679435}. |
| Mouse PG classification | NA |
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