Gene Information | |
---|---|
Gene Name | DOCK3 |
Organism | Homo sapiens (Human) |
Gene Length | 2030 |
Protein Names | Dedicator of cytokinesis protein 3 (Modifier of cell adhesion) (Presenilin-binding protein) (PBP) |
Target Name | NA |
Target Type | NA |
Gene Age | 680 ( ENSG00000088538 ) |
Evolutionary Stage | Eukaryota |
AlphaFoldDB | Q8IZD9 |
Gene Card | DOCK3 |
Uniprot ID | Q8IZD9 |
Pfam | PF06920; PF20422; PF20421; PF14429; PF16172; PF07653 |
In ASD | no |
Allosteric Prediction | yes (0.096363162) |
Ortholog in Animals | Alpaca_ DOCK3 ( ortholog_one2one ) Dog_ DOCK3 ( ortholog_one2one ) GuineaPig_ DOCK3 ( ortholog_one2one ) Macaque_ DOCK3 ( ortholog_one2one ) Mouse_ Dock3 ( ortholog_one2one ) Pig_ DOCK3 ( ortholog_one2one ) Rat_ Dock3 ( ortholog_one2one ) Rabbit_ DOCK3 ( ortholog_one2one ) |
Ohnologs | DOCK4 |
Paralogs | DOCK6, DOCK9, DOCK8, DOCK2, DOCK1, DOCK4, DOCK10, DOCK11, DOCK5, DOCK7 |
Tissue | brain, cerebral.cortex |
Tissue Specificity | In normal brains, it is localized in the neuropil, and occasionally in the pyramidal cells, while in Alzheimer disease brains, it is associated with neurofibrillary tangles. {ECO:0000269|PubMed:11696419}. |
Pharmacological Animal Models | NA |
Gene Ontology (biological process) |
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Gene Ontology (cellular component) |
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Gene Ontology (molecular function) |
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PDB | NA |
DBSNP | rs199600118 rs201184598 rs142515812 |
Subcellular location [CC] | Cytoplasm {ECO:0000250}. |
Mouse PG classification | NA |
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