| Gene Information | |
|---|---|
| Gene Name | DOC2A |
| Organism | Homo sapiens (Human) |
| Gene Length | 400 |
| Protein Names | Double C2-like domain-containing protein alpha (Doc2) (Doc2-alpha) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000149927 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q14183 |
| Gene Card | DOC2A |
| Uniprot ID | Q14183 |
| Pfam | PF00168 |
| In ASD | no |
| Allosteric Prediction | no (-0.648268341) |
| Ortholog in Animals | Alpaca_ DOC2A ( ortholog_one2one ) Dog_ DOC2A ( ortholog_one2one ) GuineaPig_ DOC2A ( ortholog_one2one ) Macaque_ DOC2A ( ortholog_one2one ) Mouse_ Doc2a ( ortholog_one2one ) Pig_ DOC2A ( ortholog_one2one ) Rat_ Doc2a ( ortholog_one2one ) Rabbit_ DOC2A ( ortholog_one2one ) |
| Ohnologs | RPH3A |
| Paralogs | SYT2, SYTL3, SYT13, TC2N, SYT1, SYT7, SYTL4, SYTL5, DOC2B, SYT14, C2CD4C, SYTL1, RPH3A, SYT8, SYT4, SYT11, SYT12, C2CD4A, C2CD4B, RPH3AL, SYT15, SYT15B, SYT9, SYT16, SYT6, C2CD4D, SYT3, SYTL2, SYT10, SYT5, SYT17 |
| Tissue | brain, testis, cerebral.cortex, cerebellar.hemisphere, cerebellum |
| Tissue Specificity | Predominantly expressed in brain. Also expressed in testis. {ECO:0000269|PubMed:7826360, ECO:0000269|PubMed:8554557}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4MJJ (X-ray 2.00A ) |
| DBSNP | rs1140239 |
| Subcellular location [CC] | Lysosome {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Synapse, synaptosome. |
| Mouse PG classification | NA |
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