| Gene Information | |
|---|---|
| Gene Name | DOBI |
| Organism | Homo sapiens (Human) |
| Gene Length | 529 |
| Protein Names | tRNA pseudouridine synthase Pus10 (Hup10) (EC 5.4.99.25) (Coiled-coil domain-containing protein 139) (tRNA pseudouridine 55 synthase) (Psi55 synthase) (tRNA pseudouridylate synthase) (tRNA-uridine isomerase) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q3MIT2 |
| Gene Card | PUS10 |
| Uniprot ID | Q3MIT2 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.2(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2V9K (X-ray 2.00A ) |
| DBSNP | rs1486089321 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:28981101, ECO:0000269|PubMed:30530625, ECO:0000269|PubMed:31819270, ECO:0000269|PubMed:33023933}. Cytoplasm {ECO:0000269|PubMed:31819270, ECO:0000269|PubMed:33023933, ECO:0000305|PubMed:30530625}. Mitochondrion {ECO:0000269|PubMed:28981101}. Note=Localizes mainly in the nucleus (Probable) (PubMed:31819270). tRNA pseudouridylate synthase activity is restricted to the cytoplasm (PubMed:31819270). Translocates from nucleus to mitochondria during TRAIL-induced apoptosis (PubMed:28981101). {ECO:0000269|PubMed:28981101, ECO:0000269|PubMed:31819270, ECO:0000305|PubMed:30530625}. |
| Mouse PG classification | NA |
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