| Gene Information | |
|---|---|
| Gene Name | DNMT3B |
| Organism | Homo sapiens (Human) |
| Gene Length | 853 |
| Protein Names | DNA (cytosine-5)-methyltransferase 3B (Dnmt3b) (EC 2.1.1.37) (DNA methyltransferase HsaIIIB) (DNA MTase HsaIIIB) (M.HsaIIIB) |
| Target Name | dna [cytosine-5]-methyltransferase 3b |
| Target Type | Clinical trial target |
| Gene Age | 645 ( ENSG00000088305 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9UBC3 |
| Gene Card | DNMT3B |
| Uniprot ID | Q9UBC3 |
| Pfam | PF17980; PF00145; PF00855 |
| In ASD | no |
| Allosteric Prediction | yes (1.026505718) |
| Ortholog in Animals | Alpaca_ DNMT3B ( ortholog_one2one ) Dog_ DNMT3B ( ortholog_one2one ) GuineaPig_ DNMT3B ( ortholog_one2one ) Macaque_ DNMT3B ( ortholog_one2one ) Mouse_ Dnmt3b ( ortholog_one2many ) Mouse_ Dnmt3c ( ortholog_one2many ) Pig_ DNMT3B ( ortholog_one2one ) Rat_ Dnmt3c ( ortholog_one2many ) Rat_ Dnmt3b ( ortholog_one2many ) Rabbit_ DNMT3B ( ortholog_one2one ) |
| Ohnologs | DNMT3A |
| Paralogs | DNMT3L, PWWP2B, PWWP2A, DNMT3A |
| Tissue | NA |
| Tissue Specificity | Ubiquitous; highly expressed in fetal liver, heart, kidney, placenta, and at lower levels in spleen, colon, brain, liver, small intestine, lung, peripheral blood mononuclear cells, and skeletal muscle. Isoform 1 is expressed in all tissues except brain, skeletal muscle and PBMC, 3 is ubiquitous, 4 is expressed in all tissues except brain, skeletal muscle, lung and prostate and 5 is detectable only in testis and at very low level in brain and prostate. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002369(Rat);0.012121(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 3FLG (X-ray 1.80A ) 3QKJ (X-ray 2.04A ) 5CIU (X-ray 2.24A ) 5NR3 (X-ray 2.30A ) 5NRR (X-ray 1.70A ) 5NRS (X-ray 2.30A ) 5NRV (X-ray 2.08A ) 5NV0 (X-ray 2.40A ) 5NV2 (X-ray 2.03A ) 5NV7 (X-ray 2.57A ) 5NVO (X-ray 2.40A ) 6KDA (X-ray 2.91A ) 6KDB (X-ray 2.86A ) 6KDL (X-ray 3.27A ) 6KDP (X-ray 2.93A ) 6KDT (X-ray 2.87A ) 6PA7 (EM 2.94A ) 6R3E (X-ray 2.27A ) 6U8P (X-ray 3.05A ) 6U8V (X-ray 3.00A ) 6U8W (X-ray 2.95A ) 6U8X (X-ray 2.95A ) 6U90 (X-ray 3.00A ) 6U91 (X-ray 3.00A ) 7O45 (X-ray 2.10A ) 7V0E (X-ray 3.27A ) |
| DBSNP | rs17123590 rs121908947 rs750849178 rs121908943 rs867732105 rs121908942 rs889145646 rs121908941 rs1191203668 rs1219696128 rs121908939 rs121908940 rs866792483 rs121908946 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:11735126, ECO:0000269|PubMed:12145218}. |
| Mouse PG classification | NA |
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