| Gene Information | |
|---|---|
| Gene Name | DNMT |
| Organism | Homo sapiens (Human) |
| Gene Length | 1616 |
| Protein Names | DNA (cytosine-5)-methyltransferase 1 (Dnmt1) (EC 2.1.1.37) (CXXC-type zinc finger protein 9) (DNA methyltransferase HsaI) (DNA MTase HsaI) (M.HsaI) (MCMT) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | P26358 |
| Gene Card | DNMT1 |
| Uniprot ID | P26358 |
| Pfam | PF01426; PF06464; PF00145; PF12047; PF02008 |
| In ASD | yes |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Ubiquitous; highly expressed in fetal tissues, heart, kidney, placenta, peripheral blood mononuclear cells, and expressed at lower levels in spleen, lung, brain, small intestine, colon, liver, and skeletal muscle. Isoform 2 is less expressed than isoform 1. {ECO:0000269|PubMed:10325416}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002865(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3EPZ (X-ray 2.31A ) 3PTA (X-ray 3.60A ) 3SWR (X-ray 2.49A ) 4WXX (X-ray 2.62A ) 4YOC (X-ray 2.92A ) 4Z96 (X-ray 2.85A ) 4Z97 (X-ray 3.00A ) 5WVO (X-ray 2.00A ) 5YDR (X-ray 2.00A ) 6K3A (X-ray 2.30A ) 6L1F (X-ray 1.90A ) 6X9I (X-ray 2.20A ) 6X9J (X-ray 1.79A ) 6X9K (X-ray 2.65A ) 7SFC (X-ray 1.97A ) 7SFD (X-ray 2.09A ) 7SFE (X-ray 2.55A ) 7SFF (X-ray 2.05A ) 7SFG (X-ray 2.43A ) |
| DBSNP | rs16999593 rs2228612 rs199473691 rs199473690 rs397509392 rs397509393 rs397509391 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:12145218}. |
| Mouse PG classification | NA |
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