| Gene Information | |
|---|---|
| Gene Name | ABCA2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 2435 |
| Protein Names | ATP-binding cassette sub-family A member 2 (EC 7.6.2.-) (ATP-binding cassette transporter 2) (ATP-binding cassette 2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000107331 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9BZC7 |
| Gene Card | ABCA2 |
| Uniprot ID | Q9BZC7 |
| Pfam | PF00005 |
| In ASD | no |
| Allosteric Prediction | no (-0.191214666) |
| Ortholog in Animals | Alpaca_ ABCA2 ( ortholog_one2one ) GuineaPig_ ABCA2 ( ortholog_one2one ) Macaque_ ABCA2 ( ortholog_one2one ) Mouse_ Abca2 ( ortholog_one2one ) Pig_ ABCA2 ( ortholog_one2one ) Rat_ Abca2 ( ortholog_one2one ) |
| Ohnologs | ABCA1 |
| Paralogs | ABCA5, ABCA9, ABCA12, ABCA7, ABCA8, ABCA13, ABCA3, ABCA1, ABCA6, ABCA10, ABCA4 |
| Tissue | NA |
| Tissue Specificity | [Isoform 3]: Highly expressed in the brain,peripheral blood leukocytes and ovary, whereas lower levels of expression is observed in kidney and liver. {ECO:0000269|PubMed:11309290, ECO:0000269|PubMed:15093135}.; [Isoform 4]: Weakly expressed in brain and highly in peripheral blood leukocytes. {ECO:0000269|PubMed:15093135}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs1588524458 rs908828 rs2090625 |
| Subcellular location [CC] | Endosome membrane {ECO:0000269|PubMed:11309290, ECO:0000269|PubMed:15093135}; Multi-pass membrane protein {ECO:0000269|PubMed:11309290}. Lysosome membrane {ECO:0000269|PubMed:11309290, ECO:0000269|PubMed:15093135}; Multi-pass membrane protein {ECO:0000269|PubMed:11309290}. Note=Forms discrete, punctate intracellular vesicles. {ECO:0000269|PubMed:11309290}. |
| Mouse PG classification | NA |
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