| Gene Information | |
|---|---|
| Gene Name | DNASE2B |
| Organism | Homo sapiens (Human) |
| Gene Length | 361 |
| Protein Names | Deoxyribonuclease-2-beta (EC 3.1.22.1) (DNase II-like acid DNase) (DNase2-like acid DNase) (Deoxyribonuclease II beta) (DNase II beta) (Endonuclease DLAD) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000137976 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q8WZ79 |
| Gene Card | DNASE2B |
| Uniprot ID | Q8WZ79 |
| Pfam | PF03265 |
| In ASD | no |
| Allosteric Prediction | no (-1.165898877) |
| Ortholog in Animals | Alpaca_ DNASE2B ( ortholog_one2one ) Dog_ DNASE2B ( ortholog_one2one ) GuineaPig_ DNASE2B ( ortholog_one2one ) Macaque_ DNASE2B ( ortholog_one2one ) Mouse_ Dnase2b ( ortholog_one2one ) Pig_ DNASE2B ( ortholog_one2one ) Rat_ Dnase2b ( ortholog_one2one ) |
| Ohnologs | DNASE2 |
| Paralogs | DNASE2 |
| Tissue | salivary.gland, parotid.gland |
| Tissue Specificity | Highly expressed in the eye lens and in salivary gland. Detected at lower levels in lung, prostate and lymph node. Isoform 2 is lung specific. {ECO:0000269|PubMed:11376952, ECO:0000269|PubMed:11700027, ECO:0000269|PubMed:12944971}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs3738573 rs3754274 rs3754274 |
| Subcellular location [CC] | Lysosome {ECO:0000305}. |
| Mouse PG classification | NA |
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