Gene Information
Gene NameSMYD2
OrganismHomo sapiens (Human)
Gene Length433
Protein NamesN-lysine methyltransferase SMYD2 (EC 2.1.1.-) (HSKM-B) (Histone methyltransferase SMYD2) (EC 2.1.1.354) (Lysine N-methyltransferase 3C) (SET and MYND domain-containing protein 2)
Target Nameset and mynd domain-containing protein 2
Target TypePreclinical target
Gene Age>4290 ( ENSG00000143499 )
Evolutionary StageEukaryota
AlphaFoldDBQ9NRG4
Gene CardSMYD2
Uniprot IDQ9NRG4
PfamPF00856; PF01753
In ASDno
Allosteric Predictionno (-0.608327638)
Ortholog in AnimalsAlpaca_ SMYD2 ( ortholog_one2one )
Dog_ SMYD2 ( ortholog_one2one )
GuineaPig_ SMYD2 ( ortholog_one2one )
Macaque_ SMYD2 ( ortholog_one2one )
Mouse_ Smyd2 ( ortholog_one2one )
Pig_ SMYD2 ( ortholog_one2one )
Rat_ Smyd2 ( ortholog_one2one )
Rabbit_ SMYD2 ( ortholog_one2one )
OhnologsSMYD1
ParalogsSMYD4, SMYD5, SMYD3, ZMYND15, SMYD1
Tissueheart, left.ventricle, pulmonary.valve
Tissue SpecificityNA
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 3RIB  (X-ray  2.79A  3S7B  (X-ray  2.42A  3S7D  (X-ray  2.30A  3S7F  (X-ray  2.85A  3S7J  (X-ray  3.04A  3TG4  (X-ray  2.00A  3TG5  (X-ray  2.30A  4O6F  (X-ray  2.82A  4WUY  (X-ray  1.63A  4YND  (X-ray  2.79A  5ARF  (X-ray  1.92A  5ARG  (X-ray  1.99A  5KJK  (X-ray  1.93A  5KJL  (X-ray  2.70A  5KJM  (X-ray  2.19A  5KJN  (X-ray  2.72A  5V3H  (X-ray  2.69A  5WCG  (X-ray  2.02A  6CBX  (X-ray  1.94A  6CBY  (X-ray  2.55A  6MON  (X-ray  2.71A  6N3G  (X-ray  2.43A 
DBSNP rs1134647  rs11120301 
Subcellular location [CC]Cytoplasm, cytosol {ECO:0000250}. Nucleus {ECO:0000250}.
Mouse PG classificationNA
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