| Gene Information | |
|---|---|
| Gene Name | DNAH8 |
| Organism | Homo sapiens (Human) |
| Gene Length | 4490 |
| Protein Names | Dynein axonemal heavy chain 8 (Axonemal beta dynein heavy chain 8) (Ciliary dynein heavy chain 8) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000124721 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | NA |
| Gene Card | DNAH8 |
| Uniprot ID | Q96JB1 |
| Pfam | PF12774; PF12780; PF12781; PF17857; PF18198; PF08385; PF08393; PF17852; PF18199; PF03028; PF12777 |
| In ASD | no |
| Allosteric Prediction | yes (0.336671218) |
| Ortholog in Animals | Alpaca_ DNAH8 ( ortholog_one2one ) Dog_ DNAH8 ( ortholog_one2one ) GuineaPig_ DNAH8 ( ortholog_one2one ) Macaque_ DNAH8 ( ortholog_one2one ) Mouse_ Dnah8 ( ortholog_one2one ) Pig_ DNAH8 ( ortholog_one2one ) Rat_ Dnah8 ( ortholog_one2one ) Rabbit_ DNAH8 ( ortholog_one2one ) |
| Ohnologs | DNAH1, DNAH7 |
| Paralogs | DNAH3, DNHD1, DNAH14, DNAH9, DYNC1H1, DNAH12, DNAH2, DNAH17, DYNC2H1, DNAH7, DNAH10, DNAH6, DNAH1, DNAH5, DNAH11 |
| Tissue | testis |
| Tissue Specificity | Expressed in spermatozoa (at protein level). Not detected in airway epithelial cells (at protein level). {ECO:0000269|PubMed:31178125}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs6935293 rs1738254 rs3823430 rs1678674 rs874808 rs9357283 rs1563044711 rs862432 rs151313083 rs61757218 rs369473998 rs1537232 rs10484847 |
| Subcellular location [CC] | Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000269|PubMed:31178125, ECO:0000269|PubMed:32619401}. Cytoplasm {ECO:0000250|UniProtKB:Q91XQ0}. Note=Detected in sperm tail, with almost exclusive localization to the principal piece. Also detected in the cytoplasm of primary spermatocytes. {ECO:0000250|UniProtKB:Q91XQ0}. |
| Mouse PG classification | NA |
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