| Gene Information | |
|---|---|
| Gene Name | ENTPD1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 510 |
| Protein Names | Ectonucleoside triphosphate diphosphohydrolase 1 (NTPDase 1) (EC 3.6.1.5) (Ecto-ATP diphosphohydrolase 1) (Ecto-ATPDase 1) (Ecto-ATPase 1) (Ecto-apyrase) (Lymphoid cell activation antigen) (CD antigen CD39) |
| Target Name | ectonucleoside triphosphate diphosphohydrolase 1 |
| Target Type | Clinical trial target |
| Gene Age | 645 ( ENSG00000138185 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P49961 |
| Gene Card | ENTPD1 |
| Uniprot ID | P49961 |
| Pfam | PF01150 |
| In ASD | yes |
| Allosteric Prediction | yes (1.00309522) |
| Ortholog in Animals | Alpaca_ ENTPD1 ( ortholog_one2one ) Dog_ ENTPD1 ( ortholog_one2one ) GuineaPig_ ENTPD1 ( ortholog_one2one ) Macaque_ ENTPD1 ( ortholog_one2one ) Mouse_ Entpd1 ( ortholog_one2one ) Pig_ ENTPD1 ( ortholog_one2one ) Rat_ Entpd1 ( ortholog_one2one ) Rabbit_ ENTPD1 ( ortholog_one2one ) |
| Ohnologs | ENTPD4 |
| Paralogs | ENTPD8, ENTPD2, ENTPD3, ENTPD5, ENTPD6, ENTPD4, ENTPD7 |
| Tissue | NA |
| Tissue Specificity | Expressed primarily on activated lymphoid cells. Also expressed in endothelial tissues. Isoform 1 and isoform 3 are present in both placenta and umbilical vein, whereas isoform 2 is present in placenta only. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs1566229309 rs3793744 |
| Subcellular location [CC] | Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. |
| Mouse PG classification | LPG |
| click here to return to the previous page | |