| Gene Information | |
|---|---|
| Gene Name | DNAAF1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 725 |
| Protein Names | Dynein axonemal assembly factor 1 (Leucine-rich repeat-containing protein 50) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000154099 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q8NEP3 |
| Gene Card | DNAAF1 |
| Uniprot ID | Q8NEP3 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | no (-1.744658962) |
| Ortholog in Animals | Alpaca_ DNAAF1 ( ortholog_one2one ) Dog_ DNAAF1 ( ortholog_one2one ) GuineaPig_ DNAAF1 ( ortholog_one2one ) Macaque_ DNAAF1 ( ortholog_one2one ) Mouse_ Dnaaf1 ( ortholog_one2one ) Pig_ DNAAF1 ( ortholog_one2one ) Rat_ Dnaaf1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | LRRC43, DNAAF11, DRC3, LRRCC1, LRRC9, LRRC46, LRRC49, CEP97, LRRC23, PPP1R42, LRRC61, LRRIQ3, LRGUK |
| Tissue | testis, oviduct |
| Tissue Specificity | Mainly expressed in trachea and testis. {ECO:0000269|PubMed:19944405}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.2(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs267607227 rs36062234 rs17856705 rs9972733 rs11644164 rs17856706 rs2288020 rs2288022 rs2288021 rs2288023 rs4150188 rs4150187 |
| Subcellular location [CC] | Cell projection, cilium {ECO:0000269|PubMed:18385425}. Cytoplasm {ECO:0000269|PubMed:18385425}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:18385425}. Note=In HEK293T cells, it is diffusely cytoplasmic and concentrates at the mitotic spindle poles, while in MDCK cells, it localizes in the cilium. In vivo, this protein is probably restricted to the cilium. |
| Mouse PG classification | NA |
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