| Gene Information | |
|---|---|
| Gene Name | BCCIP |
| Organism | Homo sapiens (Human) |
| Gene Length | 314 |
| Protein Names | BRCA2 and CDKN1A-interacting protein (P21- and CDK-associated protein 1) (Protein TOK-1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000107949 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9P287 |
| Gene Card | BCCIP |
| Uniprot ID | Q9P287 |
| Pfam | PF13862 |
| In ASD | no |
| Allosteric Prediction | no (-0.669992729) |
| Ortholog in Animals | Alpaca_ BCCIP ( ortholog_one2one ) Dog_ BCCIP ( ortholog_one2many ) GuineaPig_ BCCIP ( ortholog_one2one ) Mouse_ Bccip ( ortholog_one2one ) Pig_ BCCIP ( ortholog_one2one ) Rat_ Bccip ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed at high levels in testis and skeletal muscle and at lower levels in brain, heart, kidney, liver, lung, ovary, pancreas, placenta, and spleen. {ECO:0000269|PubMed:10878006, ECO:0000269|PubMed:11313963}. |
| Pharmacological Animal Models | NULL(Chimpanzee);0.021238(Mouse);0.002865(Rat);0.042105(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 7KYQ (X-ray 3.06A ) 7KYS (X-ray 2.20A ) |
| DBSNP | rs17153610 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:10878006, ECO:0000269|PubMed:11313963, ECO:0000269|PubMed:15713648}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:28394342}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:28394342}. Note=Colocalizes with BRCA2 in discrete nuclear foci (PubMed:15713648). In interphase, preferential localizes to the mother centriole (PubMed:28394342). Recruited to the spindle pole matrix and centrosome by microtubules and dynein/dynactin activity (PubMed:28394342). {ECO:0000269|PubMed:15713648, ECO:0000269|PubMed:28394342}.; [Isoform 1]: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:28394342}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:28394342}. Note=Isoform 1/beta tends to be less abundant at, and less strongly associated with, centrosomes than isoform 2/alpha. {ECO:0000269|PubMed:28394342}.; [Isoform 2]: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:28394342}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:28394342}. Note=Isoform 2/alpha tends to be more abundant at, and more strongly associated with, centrosomes than isoform 1/beta. {ECO:0000269|PubMed:28394342}. |
| Mouse PG classification | NA |
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