| Gene Information | |
|---|---|
| Gene Name | DMP1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 760 |
| Protein Names | Cyclin-D-binding Myb-like transcription factor 1 (hDMTF1) (Cyclin-D-interacting Myb-like protein 1) (hDMP1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 424 ( ENSG00000152592 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | Q9Y222 |
| Gene Card | DMTF1 |
| Uniprot ID | Q9Y222 |
| Pfam | PF20588; PF00249 |
| In ASD | no |
| Allosteric Prediction | no (-0.15373231) |
| Ortholog in Animals | Alpaca_ DMP1 ( ortholog_one2one ) Dog_ DMP1 ( ortholog_one2one ) GuineaPig_ DMP1 ( ortholog_one2one ) Macaque_ DMP1 ( ortholog_one2one ) Mouse_ Dmp1 ( ortholog_one2one ) Pig_ DMP1 ( ortholog_one2one ) Rat_ Dmp1 ( ortholog_one2one ) Rabbit_ DMP1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed at relatively low levels in colonic mucosa, ovary, peripheral leukocytes, prostate and small intestine, and at higher levels in spleen, testis and thymus. Expressed in multiple regions of the brain and CNS including amygdala, caudate, corpus callosum, hippocampus, substantia nigra and subthalamic nucleus. Isoform 1 is the predominant isoform in monocytes, macrophages and neutrophils, isoform 2 is most strongly expressed in peripheral blood leukocytes and quiescent CD34 positive cells, and isoform 3 is expressed at low levels in all hematopoietic cell types. Expression is frequently reduced in non-small-cell lung carcinomas (NSCLC) due to hemizygous gene deletion, strongly suggesting that this locus is haploinsufficient for tumor suppression. Loss of this locus frequently occurs in tumors which retain wild-type CDKN2A/ARF and p53/TP53 loci. Hemizygous gene deletion has also been observed in leukemic blasts from patients with abnormalities of the long arm of chromosome 7. {ECO:0000269|PubMed:10095122, ECO:0000269|PubMed:12917399, ECO:0000269|PubMed:17936562}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2LLK (NMR - ) |
| DBSNP | rs1558049 |
| Subcellular location [CC] | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00625, ECO:0000269|PubMed:17936562}. |
| Mouse PG classification | HPG |
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