| Gene Information | |
|---|---|
| Gene Name | DMP1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 513 |
| Protein Names | Dentin matrix acidic phosphoprotein 1 (DMP-1) (Dentin matrix protein 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 424 ( ENSG00000152592 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | Q13316 |
| Gene Card | DMP1 |
| Uniprot ID | Q13316 |
| Pfam | PF07263 |
| In ASD | no |
| Allosteric Prediction | no (-0.15373231) |
| Ortholog in Animals | Alpaca_ DMP1 ( ortholog_one2one ) Dog_ DMP1 ( ortholog_one2one ) GuineaPig_ DMP1 ( ortholog_one2one ) Macaque_ DMP1 ( ortholog_one2one ) Mouse_ Dmp1 ( ortholog_one2one ) Pig_ DMP1 ( ortholog_one2one ) Rat_ Dmp1 ( ortholog_one2one ) Rabbit_ DMP1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed in tooth particularly in odontoblast, ameloblast and cementoblast. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs10019009 rs140719182 rs145237146 rs34661425 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:12615915}. Cytoplasm {ECO:0000269|PubMed:12615915}. Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:12615915}. Note=In proliferating preosteoblasts it is nuclear, during early maturation stage is cytoplasmic and in mature osteoblast localizes in the mineralized matrix. Export from the nucleus of differentiating osteoblast is triggered by the release of calcium from intracellular stores followed by a massive influx of this pool of calcium into the nucleus. |
| Mouse PG classification | HPG |
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