| Gene Information | |
|---|---|
| Gene Name | DMC1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 788 |
| Protein Names | Protein HID1 (Down-regulated in multiple cancers 1) (HID1 domain-containing protein) (Protein hid-1 homolog) |
| Target Name | meiotic recombination protein dmc1/lim15 homolog |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000100206 ) |
| Evolutionary Stage | Euk_Archaea |
| AlphaFoldDB | Q8IV36 |
| Gene Card | HID1 |
| Uniprot ID | Q8IV36 |
| Pfam | PF12722 |
| In ASD | no |
| Allosteric Prediction | no (-0.098225679) |
| Ortholog in Animals | Alpaca_ DMC1 ( ortholog_one2one ) Dog_ DMC1 ( ortholog_one2one ) GuineaPig_ DMC1 ( ortholog_one2one ) Mouse_ Dmc1 ( ortholog_one2one ) Pig_ DMC1 ( ortholog_one2one ) Rat_ Dmc1 ( ortholog_one2one ) Rabbit_ DMC1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | RAD51D, RAD51, XRCC3, RAD51C, XRCC2, RAD51B |
| Tissue | testis |
| Tissue Specificity | Expressed in heart, skeletal muscle, colon, spleen, kidney, liver, small intestine and lung. Highest expression is seen in brain and placenta. Loss of expression is seen in some breast, cervical, hepatocellular, lung, thyroid, gastric and renal cell-cancer lines. Highly expressed in secretory cell lines. {ECO:0000269|PubMed:11281419, ECO:0000269|PubMed:21337012}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:21337012}. Golgi apparatus membrane {ECO:0000269|PubMed:21337012}; Lipid-anchor {ECO:0000269|PubMed:21337012}. Note=Shuttles between the cytosol and the Golgi apparatus. |
| Mouse PG classification | NA |
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