| Gene Information | |
|---|---|
| Gene Name | DMBT1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 2413 |
| Protein Names | Deleted in malignant brain tumors 1 protein (Glycoprotein 340) (Gp-340) (Hensin) (Salivary agglutinin) (SAG) (Surfactant pulmonary-associated D-binding protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000187908 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9UGM3 |
| Gene Card | DMBT1 |
| Uniprot ID | Q9UGM3 |
| Pfam | PF00431; PF00530; PF00100 |
| In ASD | no |
| Allosteric Prediction | no (-0.744898035) |
| Ortholog in Animals | Alpaca_ DMBT1 ( ortholog_one2one ) Mouse_ Dmbt1 ( ortholog_one2one ) Rat_ AABR07005844.1 ( ortholog_one2many ) Rat_ AABR07005821.1 ( ortholog_one2many ) |
| Ohnologs | NA |
| Paralogs | CD6, LOX, SSC4D, SSC5D, LGALS3BP, LOXL4, SCART1, CD163, PRSS12, LOXL3, CD5, LOXL1, CD5L, LOXL2, CD163L1 |
| Tissue | duodenum, parotid.gland, small.intestine, minor.salivary.gland, small.intestine.Peyers.patch |
| Tissue Specificity | Highly expressed in alveolar and macrophage tissues. In some macrophages, expression is seen on the membrane, and in other macrophages, strongly expressed in the phagosome/phagolysosome compartments. Expressed in lung, trachea, salivary gland, small intestine and stomach. In pancreas, expressed in certain cells of the islets of Langerhans. In digestive tract, confined to tissues with large epithelial surfaces. In intestinal tissue, moderately expressed in epithelial cells of the midcrypts and the crypt base. Expression is significantly elevated in intestinal tissue from patients with inflammatory bowel disease (IBD), particularly in surface epithelial and Paneth cells, but not in IBD patients with mutant NOD2. Present in crypt bases of the duodenum, in crypt tops of the colon, and in collecting ducts of the cortical kidney. Expressed in stratified squamous epithelium of vagina and in outer luminar surface and basilar region of columnar epithelial cells in cervix (at protein level). Isoform 1 is secreted to the lumen of the respiratory tract. {ECO:0000269|PubMed:10485905, ECO:0000269|PubMed:10749143, ECO:0000269|PubMed:11751412, ECO:0000269|PubMed:16796526, ECO:0000269|PubMed:17548659, ECO:0000269|PubMed:17983803, ECO:0000269|PubMed:9288095}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 6SA4 (X-ray 1.77A ) 6SA5 (X-ray 1.29A ) 6SAN (X-ray 1.36A ) |
| DBSNP | rs11523871 rs75209396 rs3013236 rs185045706 rs200664624 rs1969620 rs141757453 rs104894156 rs200713568 rs189478437 rs989419742 rs2277237 rs2277238 rs199704744 rs144450471 rs1195952221 rs2277244 rs200551848 rs566926424 rs149099696 rs761527369 rs189221852 rs7099177 rs183135544 |
| Subcellular location [CC] | Secreted {ECO:0000250}. Note=Some isoforms may be membrane-bound. Localized to the lumenal aspect of crypt cells in the small intestine. In the colon, seen in the lumenal aspect of surface epithelial cells. Formed in the ducts of von Ebner gland, and released into the fluid bathing the taste buds contained in the taste papillae (By similarity). {ECO:0000250}. |
| Mouse PG classification | NA |
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