| Gene Information | |
|---|---|
| Gene Name | DLST |
| Organism | Homo sapiens (Human) |
| Gene Length | 453 |
| Protein Names | Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial (EC 2.3.1.61) (2-oxoglutarate dehydrogenase complex component E2) (OGDC-E2) (Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex) (E2K) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1714 ( ENSG00000119689 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | P36957 |
| Gene Card | DLST |
| Uniprot ID | P36957 |
| Pfam | PF00198; PF00364 |
| In ASD | no |
| Allosteric Prediction | no (-0.081656194) |
| Ortholog in Animals | Alpaca_ DLST ( ortholog_one2one ) Dog_ DLST ( ortholog_one2one ) Macaque_ DLST ( ortholog_one2one ) Mouse_ Dlst ( ortholog_one2one ) Pig_ DLST ( ortholog_one2one ) Rat_ Dlst ( ortholog_one2one ) Rabbit_ DLST ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | PDHX, DBT, DLAT |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | 0.000730(Chimpanzee);0.001000(Mouse);NULL(Rat);0.057895(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6H05 (EM 2.90A ) |
| DBSNP | rs771616810 rs373295097 rs1270341616 rs778239022 |
| Subcellular location [CC] | Mitochondrion matrix {ECO:0000305|PubMed:29211711}. Nucleus {ECO:0000269|PubMed:29211711}. Note=Mainly localizes in the mitochondrion. A small fraction localizes to the nucleus, where the 2-oxoglutarate dehydrogenase complex is required for histone succinylation. {ECO:0000269|PubMed:29211711}. |
| Mouse PG classification | NA |
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