| Gene Information | |
|---|---|
| Gene Name | RELN |
| Organism | Homo sapiens (Human) |
| Gene Length | 3460 |
| Protein Names | Reelin (EC 3.4.21.-) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 132 ( ENSG00000189056 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | NA |
| Gene Card | RELN |
| Uniprot ID | P78509 |
| Pfam | PF18720; PF02014 |
| In ASD | no |
| Allosteric Prediction | yes (0.463986194) |
| Ortholog in Animals | Alpaca_ RELN ( ortholog_one2one ) Dog_ RELN ( ortholog_one2one ) GuineaPig_ RELN ( ortholog_one2one ) Macaque_ RELN ( ortholog_one2one ) Mouse_ Reln ( ortholog_one2one ) Pig_ RELN ( ortholog_one2one ) Rat_ Reln ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | liver, cerebellum, brain, cerebellar.hemisphere |
| Tissue Specificity | Abundantly produced during brain ontogenesis by the Cajal-Retzius cells and other pioneer neurons located in the telencephalic marginal zone and by granule cells of the external granular layer of the cerebellum. In adult brain, preferentially expressed in GABAergic interneurons of prefrontal cortices, temporal cortex, hippocampus and glutamatergic granule cells of cerebellum. Expression is reduced to about 50% in patients with schizophrenia. Also expressed in fetal and adult liver. {ECO:0000269|PubMed:9861036}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs201044262 rs768119894 rs794727998 rs794727996 rs797045000 rs3025962 rs362691 rs2229860 rs794727997 rs794727999 |
| Subcellular location [CC] | Secreted, extracellular space, extracellular matrix {ECO:0000250}. |
| Mouse PG classification | NA |
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