| Gene Information | |
|---|---|
| Gene Name | DLM1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 429 |
| Protein Names | Z-DNA-binding protein 1 (DNA-dependent activator of IFN-regulatory factors) (DAI) (Tumor stroma and activated macrophage protein DLM-1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q9H171 |
| Gene Card | ZBP1 |
| Uniprot ID | Q9H171 |
| Pfam | PF02295 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Highly expressed in lymphatic tissues including lymph node, leukocytes, tonsil, bone marrow and spleen (PubMed:11842111). Expressed to a lesser extent in thymus, lung and liver (PubMed:11842111). {ECO:0000269|PubMed:11842111}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2L4M (NMR - ) 2LNB (NMR - ) 3EYI (X-ray 1.45A ) 4KA4 (X-ray 2.60A ) |
| DBSNP | rs35813125 rs35895307 rs34964609 rs2073145 rs16981187 rs34478944 rs2865394 rs41275648 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:16876127, ECO:0000269|PubMed:16990255}. Nucleus {ECO:0000269|PubMed:16876127, ECO:0000269|PubMed:16990255}. Note=Mainly cytoplasmic (PubMed:16876127, PubMed:16990255). Accumulates in the nucleus in response to influenza A virus (IAV) infection: senses IAV defective viral genomes RNA in the nucleus (By similarity). {ECO:0000250|UniProtKB:Q9QY24, ECO:0000269|PubMed:16876127, ECO:0000269|PubMed:16990255}.; [Isoform 7]: Cytoplasm {ECO:0000269|PubMed:16876127, ECO:0000269|PubMed:16990255}. Nucleus {ECO:0000269|PubMed:16876127, ECO:0000269|PubMed:16990255}. Note=Compared to isoform 1, a higher proportion of this isoform is localized in the nucleus. {ECO:0000269|PubMed:16876127, ECO:0000269|PubMed:16990255}. |
| Mouse PG classification | NA |
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