| Gene Information | |
|---|---|
| Gene Name | CSMD2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 3487 |
| Protein Names | CUB and sushi domain-containing protein 2 (CUB and sushi multiple domains protein 2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000121904 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | NA |
| Gene Card | CSMD2 |
| Uniprot ID | Q7Z408 |
| Pfam | PF00431; PF00084 |
| In ASD | no |
| Allosteric Prediction | no (-0.522383977) |
| Ortholog in Animals | Alpaca_ CSMD2 ( ortholog_one2one ) GuineaPig_ CSMD2 ( ortholog_one2one ) Macaque_ CSMD2 ( ortholog_one2one ) Mouse_ Csmd2 ( ortholog_one2one ) Rat_ Csmd2 ( ortholog_one2one ) Rabbit_ CSMD2 ( ortholog_one2one ) |
| Ohnologs | CSMD3, CSMD1 |
| Paralogs | CR1L, SUSD3, F13B, SELP, SEZ6L2, CFHR2, CFHR1, CSMD1, APOH, SELE, SRPX, SVEP1, SEZ6, C8A, CD55, PAPPA2, SUSD6, C4BPA, C9, CR1, PAPPA, SELL, CFB, CD46, C4BPB, CR2, C7, CSMD3, CFHR3, CFH, SEZ6L, CFHR4, CFHR5, SRPX2, C8B, PRF1, SUSD4, C6, C2 |
| Tissue | NA |
| Tissue Specificity | Weakly expressed in most tissues, except in brain. Expressed at intermediate level in brain, including cerebellum, substantia nigra, hippocampus and fetal brain. Overexpressed in some head and neck cancer cell lines. {ECO:0000269|PubMed:11572484, ECO:0000269|PubMed:12906867}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs16836099 rs474474 rs1874045 rs11588581 rs2641962 rs3820206 rs34850622 rs1617468 |
| Subcellular location [CC] | Cell membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. |
| Mouse PG classification | NA |
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