| Gene Information | |
|---|---|
| Gene Name | DLL1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 723 |
| Protein Names | Delta-like protein 1 (Drosophila Delta homolog 1) (Delta1) (H-Delta-1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000198719 ) 3 ( ENSG00000275555 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | O00548 |
| Gene Card | DLL1 |
| Uniprot ID | O00548 |
| Pfam | PF01414; PF00008; PF12661; PF07657 |
| In ASD | no |
| Allosteric Prediction | no (-0.424074482) |
| Ortholog in Animals | Alpaca_ DLL1 ( ortholog_one2one ) GuineaPig_ DLL1 ( ortholog_one2one ) Macaque_ DLL1 ( ortholog_one2one ) Mouse_ Dll1 ( ortholog_one2one ) Pig_ DLL1 ( ortholog_one2one ) Rat_ Dll1 ( ortholog_one2one ) |
| Ohnologs | DLL4 |
| Paralogs | NOTCH4, JAG1, DNER, DLL4, JAG2 |
| Tissue | NA |
| Tissue Specificity | Expressed in heart and pancreas, with lower expression in brain and muscle and almost no expression in placenta, lung, liver and kidney. |
| Pharmacological Animal Models | 0.018801(Chimpanzee);0.001000(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4XBM (X-ray 3.20A ) |
| DBSNP | rs16901311 |
| Subcellular location [CC] | Apical cell membrane {ECO:0000250|UniProtKB:Q61483}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q61483}. Cell junction, adherens junction {ECO:0000250|UniProtKB:Q61483}. Membrane raft {ECO:0000250|UniProtKB:Q61483}. Note=Distributed around adherens junction in the apical endfeet through interactions with MAGI1. {ECO:0000250|UniProtKB:Q61483}. |
| Mouse PG classification | NA |
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