| Gene Information | |
|---|---|
| Gene Name | MIP |
| Organism | Homo sapiens (Human) |
| Gene Length | 263 |
| Protein Names | Lens fiber major intrinsic protein (Aquaporin-0) (MIP26) (MP26) |
| Target Name | lens fiber major intrinsic protein |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000135517 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P30301 |
| Gene Card | MIP |
| Uniprot ID | P30301 |
| Pfam | PF00230 |
| In ASD | no |
| Allosteric Prediction | no (-0.773324392) |
| Ortholog in Animals | Alpaca_ MIP ( ortholog_one2one ) Dog_ MIP ( ortholog_one2one ) GuineaPig_ MIP ( ortholog_one2one ) Macaque_ MIP ( ortholog_one2one ) Mouse_ Mip ( ortholog_one2one ) Pig_ MIP ( ortholog_one2one ) Rat_ Mip ( ortholog_one2one ) Rabbit_ MIP ( ortholog_one2one ) |
| Ohnologs | AQP5, AQP2, AQP4, AQP6, MINDY4 |
| Paralogs | AQP3, AQP1, AQP5, AQP4, AQP6, AQP10, AQP8, AQP7B, AQP7, AQP9, AQP2 |
| Tissue | NA |
| Tissue Specificity | Expressed in the cortex and nucleus of the retina lens (at protein level) (PubMed:30790544). Major component of lens fiber gap junctions (PubMed:24120416). {ECO:0000269|PubMed:24120416, ECO:0000269|PubMed:30790544}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs864309693 rs74641138 rs121917869 rs121917867 rs778327521 rs267603585 rs1555179699 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:23116563, ECO:0000269|PubMed:24120416, ECO:0000269|PubMed:25946197, ECO:0000269|PubMed:30790544}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q6J8I9}. Cell junction, gap junction {ECO:0000269|PubMed:24120416}. |
| Mouse PG classification | NA |
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