| Gene Information | |
|---|---|
| Gene Name | RAB20 |
| Organism | Homo sapiens (Human) |
| Gene Length | 234 |
| Protein Names | Ras-related protein Rab-20 |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000139832 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9NX57 |
| Gene Card | RAB20 |
| Uniprot ID | Q9NX57 |
| Pfam | PF00071 |
| In ASD | no |
| Allosteric Prediction | no (-1.068551716) |
| Ortholog in Animals | Dog_ RAB20 ( ortholog_one2one ) GuineaPig_ RAB20 ( ortholog_one2one ) Macaque_ RAB20 ( ortholog_one2one ) Mouse_ Rab20 ( ortholog_one2one ) Pig_ RAB20 ( ortholog_one2one ) Rat_ Rab20 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | RAB14, RAB5C, RAB39A, RAB27B, RAB36, RAB33B, RABL2A, RABL2B, RAB27A, RAB3C, RAB5A, RAB15, RAB40AL, RAB3A, RAB40C, RAB12, RAB8A, RAB17, RAB24, RAB44, RAB1A, RAB11A, RAB31, RAB7A, IFT27, RAB29, RAB33A, RAB9B, RAB10, RAB4B, RAB32, RAB4A, RAB19, RAB42, RAB9A, RAB40A, RAB11B, RAB2B, RAB2A, RAB43, RAB18, RAB37, RAB25, RASEF, RAB6D, RAB6C, RAB8B, RAB41, RAB40B, RAB21, RAB39B, RAB28, RAB5B, RAB13, RAB38, RAB3B, RAB34, RAB7B, RAB35, RAB3D, RAB1B, RAB6B, RAB22A, RAB26, RAB23, RAB30, RAB6A, DNAJC27 |
| Tissue | NA |
| Tissue Specificity | Low or absent expression in normal pancreas and stronger expression in 15 of 18 exocrine pancreatic adenocarcinomas (at protein level). {ECO:0000269|PubMed:16613320}. |
| Pharmacological Animal Models | NULL(Chimpanzee);0.001000(Mouse);0.001000(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs426453 |
| Subcellular location [CC] | Golgi apparatus {ECO:0000269|PubMed:16613320}. Cytoplasmic vesicle, phagosome {ECO:0000269|PubMed:21255211}. Cytoplasmic vesicle, phagosome membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Note=Highly enriched on apical endocytic structures in polarized epithelial cells of kidney proximal tubules (By similarity). Recruited to phagosomes containing S.aureus or M.tuberculosis (PubMed:21255211). {ECO:0000250|UniProtKB:P35295, ECO:0000269|PubMed:21255211}. |
| Mouse PG classification | NA |
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