| Gene Information | |
|---|---|
| Gene Name | DLG1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 904 |
| Protein Names | Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (SAP97) (hDlg) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000075711 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | Q12959 |
| Gene Card | DLG1 |
| Uniprot ID | Q12959 |
| Pfam | PF00625; PF09058; PF10608; PF00595; PF10600; PF00018 |
| In ASD | no |
| Allosteric Prediction | yes (1.274144601) |
| Ortholog in Animals | Alpaca_ DLG1 ( ortholog_one2one ) Dog_ DLG1 ( ortholog_one2one ) GuineaPig_ DLG1 ( ortholog_one2one ) Macaque_ DLG1 ( ortholog_one2one ) Mouse_ Dlg1 ( ortholog_one2one ) Pig_ DLG1 ( ortholog_one2one ) Rat_ Dlg1 ( ortholog_one2one ) Rabbit_ DLG1 ( ortholog_one2one ) |
| Ohnologs | DLG3, DLG4, DLG2 |
| Paralogs | DLG4, DLG3, DLG2 |
| Tissue | NA |
| Tissue Specificity | Abundantly expressed in atrial myocardium (at protein level). Expressed in lung fibroblasts, cervical epithelial and B-cells (at protein level). Expressed in the brain (at protein level) (PubMed:23676497). Widely expressed, with isoforms displaying different expression profiles. {ECO:0000269|PubMed:12445884, ECO:0000269|PubMed:19213956, ECO:0000269|PubMed:23676497, ECO:0000269|PubMed:7937897}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.028311(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 1PDR (X-ray 2.80A ) 2M3M (NMR - ) 2OQS (NMR - ) 2X7Z (X-ray 2.00A ) 3LRA (X-ray 2.95A ) 3RL7 (X-ray 2.30A ) 3RL8 (X-ray 2.20A ) 3W9Y (X-ray 2.20A ) 4AMH (X-ray 2.30A ) 4G69 (X-ray 2.00A ) 7PC3 (X-ray 1.95A ) |
| DBSNP | rs1802668 rs1134986 rs34492126 |
| Subcellular location [CC] | Membrane {ECO:0000269|PubMed:10859302, ECO:0000269|PubMed:11723125, ECO:0000269|PubMed:8922391}; Peripheral membrane protein {ECO:0000269|PubMed:8922391}. Basolateral cell membrane {ECO:0000269|PubMed:12807908}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q62696}. Postsynaptic density {ECO:0000250|UniProtKB:Q62696}. Synapse {ECO:0000250|UniProtKB:Q62696}. Cell membrane, sarcolemma {ECO:0000269|PubMed:12445884}. Apical cell membrane {ECO:0000269|PubMed:12445884}. Cell junction {ECO:0000269|PubMed:10859302, ECO:0000269|PubMed:11723125, ECO:0000269|PubMed:7937897}. Cytoplasm {ECO:0000269|PubMed:10859302}. Note=Colocalizes with EPB41 at regions of intercellular contacts. Basolateral in epithelial cells (PubMed:12807908). May also associate with endoplasmic reticulum membranes. Mainly found in neurons soma, moderately found at postsynaptic densities (By similarity). {ECO:0000250|UniProtKB:Q62696, ECO:0000269|PubMed:10859302, ECO:0000269|PubMed:12807908, ECO:0000269|PubMed:8922391, ECO:0000269|PubMed:9192623}. |
| Mouse PG classification | NA |
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