| Gene Information | |
|---|---|
| Gene Name | IMP4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 592 |
| Protein Names | Signal peptide peptidase-like 2B (SPP-like 2B) (SPPL2b) (EC 3.4.23.-) (Intramembrane protease 4) (IMP-4) (Presenilin homologous protein 4) (PSH4) (Presenilin-like protein 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000136718 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q8TCT7 |
| Gene Card | SPPL2B |
| Uniprot ID | Q8TCT7 |
| Pfam | PF02225; PF04258 |
| In ASD | no |
| Allosteric Prediction | no (-1.55173649) |
| Ortholog in Animals | Alpaca_ IMP4 ( ortholog_one2one ) GuineaPig_ IMP4 ( ortholog_one2one ) Macaque_ IMP4 ( ortholog_one2one ) Mouse_ Imp4 ( ortholog_one2one ) Pig_ IMP4 ( ortholog_one2one ) Rat_ Imp4 ( ortholog_one2one ) Rabbit_ IMP4 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | RPF1 |
| Tissue | NA |
| Tissue Specificity | Expressed predominantly in adrenal cortex and mammary gland. {ECO:0000269|PubMed:15385547}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs10402284 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:16829952}; Multi-pass membrane protein {ECO:0000305}. Golgi apparatus membrane {ECO:0000269|PubMed:17965014}; Multi-pass membrane protein {ECO:0000305}. Lysosome membrane {ECO:0000269|PubMed:15998642}; Multi-pass membrane protein {ECO:0000305}. Endosome membrane {ECO:0000269|PubMed:15998642}; Multi-pass membrane protein {ECO:0000305}. Membrane {ECO:0000269|PubMed:15385547}; Multi-pass membrane protein {ECO:0000305}; Lumenal side {ECO:0000269|PubMed:15385547}. Note=targeted through the entire secretory pathway to endosomes/lysosomes (PubMed:15998642). {ECO:0000269|PubMed:15998642}. |
| Mouse PG classification | NA |
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