| Gene Information | |
|---|---|
| Gene Name | DLD |
| Organism | Homo sapiens (Human) |
| Gene Length | 509 |
| Protein Names | Dihydrolipoyl dehydrogenase, mitochondrial (EC 1.8.1.4) (Dihydrolipoamide dehydrogenase) (Glycine cleavage system L protein) |
| Target Name | dihydrolipoyl dehydrogenase, mitochondrial |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000091140 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | P09622 |
| Gene Card | DLD |
| Uniprot ID | P09622 |
| Pfam | PF07992; PF02852 |
| In ASD | no |
| Allosteric Prediction | yes (0.070139038) |
| Ortholog in Animals | Alpaca_ DLD ( ortholog_one2one ) Dog_ DLD ( ortholog_one2one ) Macaque_ DLD ( ortholog_one2one ) Mouse_ Dld ( ortholog_one2one ) Pig_ DLD ( ortholog_one2one ) Rat_ Dld ( ortholog_one2many ) |
| Ohnologs | NA |
| Paralogs | TXNRD3, AIFM3, AIFM1, PYROXD1, TXNRD2, TXNRD1, GSR |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.083432(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1ZMC (X-ray 2.53A ) 1ZMD (X-ray 2.08A ) 1ZY8 (X-ray 2.59A ) 2F5Z (X-ray 2.18A ) 3RNM (X-ray 2.40A ) 5J5Z (X-ray 1.84A ) 5NHG (X-ray 2.27A ) 6HG8 (X-ray 1.76A ) 6I4P (X-ray 1.60A ) 6I4Q (X-ray 1.75A ) 6I4R (X-ray 1.44A ) 6I4S (X-ray 1.75A ) 6I4T (X-ray 1.82A ) 6I4U (X-ray 1.84A ) 6I4Z (X-ray 2.34A ) |
| DBSNP | rs397514651 rs121964987 rs1130477 rs121964990 rs17624 rs121964993 rs121964992 rs121964991 rs397514649 rs397514650 rs121964988 rs121964989 |
| Subcellular location [CC] | Mitochondrion matrix {ECO:0000305|PubMed:29211711, ECO:0000305|PubMed:3693355}. Nucleus {ECO:0000269|PubMed:29211711}. Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:Q811C4}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000269|PubMed:15888450}. Note=Mainly localizes in the mitochondrion. A small fraction localizes to the nucleus, where the 2-oxoglutarate dehydrogenase complex is required for histone succinylation. {ECO:0000269|PubMed:29211711}. |
| Mouse PG classification | LPG |
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