| Gene Information | |
|---|---|
| Gene Name | DLAT |
| Organism | Homo sapiens (Human) |
| Gene Length | 647 |
| Protein Names | Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial (EC 2.3.1.12) (70 kDa mitochondrial autoantigen of primary biliary cirrhosis) (PBC) (Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex) (M2 antigen complex 70 kDa subunit) (Pyruvate dehydrogenase complex component E2) (PDC-E2) (PDCE2) |
| Target Name | dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial |
| Target Type | NA |
| Gene Age | 1714 ( ENSG00000150768 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | P10515 |
| Gene Card | DLAT |
| Uniprot ID | P10515 |
| Pfam | PF00198; PF00364; PF02817 |
| In ASD | no |
| Allosteric Prediction | yes (0.301765324) |
| Ortholog in Animals | Alpaca_ DLAT ( ortholog_one2one ) Dog_ DLAT ( ortholog_one2one ) GuineaPig_ DLAT ( ortholog_one2one ) Macaque_ DLAT ( ortholog_one2one ) Mouse_ Dlat ( ortholog_one2one ) Pig_ DLAT ( ortholog_one2one ) Rat_ Dlat ( ortholog_one2many ) Rabbit_ DLAT ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | PDHX, DBT, DLST |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.052519(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1FYC (NMR - ) 1Y8N (X-ray 2.60A ) 1Y8O (X-ray 2.48A ) 1Y8P (X-ray 2.63A ) 2DNE (NMR - ) 2PNR (X-ray 2.50A ) 2Q8I (X-ray 2.60A ) 3B8K (EM 8.80A ) 3CRK (X-ray 2.30A ) 3CRL (X-ray 2.61A ) 6CT0 (EM 3.10A ) 6H55 (EM 6.00A ) |
| DBSNP | rs2303436 rs537057 rs537060 rs11553595 rs11553592 rs627441 rs10891314 |
| Subcellular location [CC] | Mitochondrion matrix. |
| Mouse PG classification | NA |
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