| Gene Information | |
|---|---|
| Gene Name | DISP3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1392 |
| Protein Names | Protein dispatched homolog 3 (Patched domain-containing protein 2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000204624 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9P2K9 |
| Gene Card | DISP3 |
| Uniprot ID | Q9P2K9 |
| Pfam | PF03176; PF02460 |
| In ASD | no |
| Allosteric Prediction | no (-0.867229449) |
| Ortholog in Animals | Alpaca_ DISP3 ( ortholog_one2one ) Dog_ DISP3 ( ortholog_one2one ) GuineaPig_ DISP3 ( ortholog_one2one ) Macaque_ DISP3 ( ortholog_one2one ) Mouse_ Disp3 ( ortholog_one2one ) Pig_ DISP3 ( ortholog_one2one ) Rat_ Disp3 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | DISP1, SCAP, NPC1, PTCHD1, PTCH2, PTCHD3, PTCHD4, NPC1L1, DISP2, PTCH1 |
| Tissue | NA |
| Tissue Specificity | Expressed in brain and testis (PubMed:15645143). {ECO:0000269|PubMed:15645143}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs41274528 rs3738159 rs2817580 rs2072994 rs2072993 rs12096312 |
| Subcellular location [CC] | Endoplasmic reticulum membrane {ECO:0000269|PubMed:19179482}; Multi-pass membrane protein {ECO:0000305}. Nucleus membrane {ECO:0000269|PubMed:19179482}; Multi-pass membrane protein {ECO:0000305}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:B9U3F2}; Multi-pass membrane protein {ECO:0000305}. Note=Predominantly localized to cholesterol-enriched domains within the membrane (PubMed:19179482). Localizes to cytoplasmic punctate vesicular structures (By similarity). {ECO:0000250|UniProtKB:B9U3F2, ECO:0000269|PubMed:19179482}. |
| Mouse PG classification | NA |
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