| Gene Information | |
|---|---|
| Gene Name | DIRAS3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 229 |
| Protein Names | GTP-binding protein Di-Ras3 (Distinct subgroup of the Ras family member 3) (Rho-related GTP-binding protein RhoI) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 382 ( ENSG00000162595 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | O95661 |
| Gene Card | DIRAS3 |
| Uniprot ID | O95661 |
| Pfam | PF00071 |
| In ASD | no |
| Allosteric Prediction | no (-0.75166607) |
| Ortholog in Animals | Alpaca_ DIRAS3 ( ortholog_one2one ) Macaque_ DIRAS3 ( ortholog_one2one ) Pig_ DIRAS3 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | RRAS, RHEB, KRAS, DIRAS1, RRAS2, RAP2B, HRAS, RERG, RASL12, RRAD, RIT1, DIRAS2, ERAS, NKIRAS1, RALB, RASD2, GEM, MRAS, RAP2A, RASD1, REM1, NKIRAS2, RALA, RAP1A, RASL11B, RAP1B, RASL10A, RASL11A, REM2, RERGL, RIT2, RHEBL1, NRAS, RAP2C, RASL10B |
| Tissue | ovary, pancreas, pituitary.gland, putamen |
| Tissue Specificity | Expressed in normal ovarian and breast epithelial cells but not in ovarian and breast cancers. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 6NAZ (X-ray 3.08A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. |
| Mouse PG classification | NA |
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