| Gene Information | |
|---|---|
| Gene Name | DIO3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 304 |
| Protein Names | Thyroxine 5-deiodinase (EC 1.21.99.3) (5DIII) (DIOIII) (Type 3 DI) (Type III iodothyronine deiodinase) |
| Target Name | thyroxine 5-deiodinase |
| Target Type | NA |
| Gene Age | 3 ( ENSG00000197406 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | NA |
| Gene Card | DIO3 |
| Uniprot ID | P55073 |
| Pfam | PF00837 |
| In ASD | no |
| Allosteric Prediction | yes (0.063341333) |
| Ortholog in Animals | Mouse_ Dio3 ( ortholog_one2one ) Pig_ DIO3 ( ortholog_one2one ) Rat_ Dio3 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | DIO2, DIO1 |
| Tissue | placenta, cervix, endocervix |
| Tissue Specificity | Expressed in placenta and several fetal tissues. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:12419801}; Single-pass type II membrane protein {ECO:0000269|PubMed:12419801}. Endosome membrane {ECO:0000269|PubMed:12419801}; Single-pass type II membrane protein {ECO:0000269|PubMed:12419801}. |
| Mouse PG classification | NA |
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