| Gene Information | |
|---|---|
| Gene Name | DIO1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 249 |
| Protein Names | Type I iodothyronine deiodinase (EC 1.21.99.4) (5DI) (DIOI) (Type 1 DI) (Type-I 5'-deiodinase) |
| Target Name | iodothyronine deiodinase type i |
| Target Type | Successful target |
| Gene Age | 680 ( ENSG00000211452 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | NA |
| Gene Card | DIO1 |
| Uniprot ID | P49895 |
| Pfam | PF00837 |
| In ASD | no |
| Allosteric Prediction | no (-0.313564101) |
| Ortholog in Animals | Alpaca_ DIO1 ( ortholog_one2one ) Dog_ DIO1 ( ortholog_one2one ) GuineaPig_ Dio1 ( ortholog_one2one ) Macaque_ DIO1 ( ortholog_one2one ) Mouse_ Dio1 ( ortholog_one2one ) Pig_ DIO1 ( ortholog_one2one ) Rat_ Dio1 ( ortholog_one2one ) Rabbit_ DIO1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | DIO2, DIO3 |
| Tissue | thyroid, kidney, liver |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs754694815 rs201420507 |
| Subcellular location [CC] | Endoplasmic reticulum membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. |
| Mouse PG classification | NA |
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