| Gene Information | |
|---|---|
| Gene Name | DICER1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1922 |
| Protein Names | Endoribonuclease Dicer (EC 3.1.26.3) (Helicase with RNase motif) (Helicase MOI) |
| Target Name | helicase-moi messenger rna |
| Target Type | Literature-reported target |
| Gene Age | 544 ( ENSG00000100697 ) |
| Evolutionary Stage | Euk_Archaea |
| AlphaFoldDB | Q9UPY3 |
| Gene Card | DICER1 |
| Uniprot ID | Q9UPY3 |
| Pfam | PF00271; PF02170; PF04851; PF00636 |
| In ASD | yes |
| Allosteric Prediction | yes (0.244888175) |
| Ortholog in Animals | Alpaca_ DICER1 ( ortholog_one2one ) Dog_ DICER1 ( ortholog_one2one ) GuineaPig_ DICER1 ( ortholog_one2one ) Macaque_ DICER1 ( ortholog_one2one ) Mouse_ Dicer1 ( ortholog_one2one ) Pig_ DICER1 ( ortholog_one2one ) Rat_ Dicer1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001303(Rat);0.023636(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2EB1 (X-ray 2.00A ) 4NGB (X-ray 2.25A ) 4NGC (X-ray 2.10A ) 4NGD (X-ray 1.96A ) 4NGF (X-ray 3.10A ) 4NGG (X-ray 2.60A ) 4NH3 (X-ray 2.62A ) 4NH5 (X-ray 2.55A ) 4NH6 (X-ray 2.55A ) 4NHA (X-ray 3.40A ) 4WYQ (X-ray 3.20A ) 5ZAK (EM 4.40A ) 5ZAL (EM 4.70A ) 5ZAM (EM 5.70A ) |
| DBSNP | rs387906934 rs137852976 rs1555366979 rs775912475 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:16424907}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:19022417}. |
| Mouse PG classification | LPG |
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