| Gene Information | |
|---|---|
| Gene Name | CISD2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 135 |
| Protein Names | CDGSH iron-sulfur domain-containing protein 2 (Endoplasmic reticulum intermembrane small protein) (MitoNEET-related 1 protein) (Miner1) (Nutrient-deprivation autophagy factor-1) (NAF-1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000145354 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q8N5K1 |
| Gene Card | CISD2 |
| Uniprot ID | Q8N5K1 |
| Pfam | PF10660; PF09360 |
| In ASD | no |
| Allosteric Prediction | no (-0.969755483) |
| Ortholog in Animals | Alpaca_ CISD2 ( ortholog_one2one ) Dog_ CISD2 ( ortholog_one2one ) GuineaPig_ CISD2 ( ortholog_one2one ) Macaque_ CISD2 ( ortholog_one2one ) Mouse_ Cisd2 ( ortholog_one2one ) Pig_ CISD2 ( ortholog_one2one ) |
| Ohnologs | CISD1 |
| Paralogs | CISD1, CISD3 |
| Tissue | NA |
| Tissue Specificity | Testis, small intestine, kidney, lung, brain, heart, pancreas and platelets. {ECO:0000269|PubMed:17846994}. |
| Pharmacological Animal Models | NULL(Chimpanzee);0.001000(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3FNV (X-ray 2.10A ) 4OO7 (X-ray 1.65A ) 4OOA (X-ray 1.58A ) 7P0P (X-ray 1.74A ) |
| DBSNP | NA |
| Subcellular location [CC] | Endoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion outer membrane; Single-pass membrane protein. Note=According to PubMed:20010695, it mainly localizes to the endoplasmic reticulum. However, experiments in mouse showed that it mainly localizes to the mitochondrion outer membrane. |
| Mouse PG classification | NA |
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