| Gene Information | |
|---|---|
| Gene Name | DIAPH1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1272 |
| Protein Names | Protein diaphanous homolog 1 (Diaphanous-related formin-1) (DRF1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000131504 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | O60610 |
| Gene Card | DIAPH1 |
| Uniprot ID | O60610 |
| Pfam | PF06367; PF06371; PF02181 |
| In ASD | no |
| Allosteric Prediction | yes (0.081428555) |
| Ortholog in Animals | Alpaca_ DIAPH1 ( ortholog_one2one ) Dog_ DIAPH1 ( ortholog_one2one ) GuineaPig_ DIAPH1 ( ortholog_one2one ) Macaque_ DIAPH1 ( ortholog_one2one ) Mouse_ Diaph1 ( ortholog_one2one ) Pig_ DIAPH1 ( ortholog_one2one ) Rat_ Diaph1 ( ortholog_one2one ) |
| Ohnologs | DIAPH3, DIAPH2 |
| Paralogs | FHOD3, FHOD1, FHDC1, GRID2IP, FAM47B, DAAM2, FNBP4, SHTN1, FAM47C, FAM47A, FMNL1, DAAM1, DIAPH3, DIAPH2, FMN2, FMNL3, FMNL2, INF2 |
| Tissue | NA |
| Tissue Specificity | Expressed in brain, heart, placenta, lung, kidney, pancreas, liver, skeletal muscle and cochlea. Expressed in platelets (PubMed:26912466). {ECO:0000269|PubMed:26912466}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs186370335 |
| Subcellular location [CC] | Cell membrane {ECO:0000250|UniProtKB:O08808}. Cell projection, ruffle membrane {ECO:0000250|UniProtKB:O08808}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:24781755}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:24781755}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:24781755}. Cytoplasm {ECO:0000250|UniProtKB:O08808}. Nucleus {ECO:0000250|UniProtKB:O08808}. Note=Membrane ruffles, especially at the tip of ruffles, of motile cells. {ECO:0000250|UniProtKB:O08808}. |
| Mouse PG classification | LPG |
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