Gene Information
Gene NameDHX9
OrganismHomo sapiens (Human)
Gene Length1270
Protein NamesATP-dependent RNA helicase A (EC 3.6.4.13) (DEAH box protein 9) (DExH-box helicase 9) (Leukophysin) (LKP) (Nuclear DNA helicase II) (NDH II) (RNA helicase A)
Target NameNA
Target TypeNA
Gene Age950 ( ENSG00000135829 )
Evolutionary StageEumetazoa
AlphaFoldDBQ08211
Gene CardDHX9
Uniprot IDQ08211
PfamPF00270; PF00035; PF04408; PF00271; PF07717
In ASDno
Allosteric Predictionno (-0.041472271)
Ortholog in AnimalsAlpaca_ DHX9 ( ortholog_one2one )
Dog_ DHX9 ( ortholog_one2one )
GuineaPig_ DHX9 ( ortholog_one2one )
Macaque_ DHX9 ( ortholog_one2one )
Mouse_ Dhx9 ( ortholog_one2one )
Pig_ DHX9 ( ortholog_one2one )
Rat_ Dhx9 ( ortholog_one2one )
Rabbit_ DHX9 ( ortholog_one2one )
OhnologsNA
ParalogsYTHDC2, DHX40, DHX34, DHX32, HELB, DHX57, DHX30, DHX29, DHX36, DHX15, DHX35, DHX38, DQX1, DHX16, DHX33, TDRD9, DHX8, DHX37
TissueNA
Tissue SpecificityNA
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 3LLM  (X-ray  2.80A  )  3VYX  (X-ray  2.29A  )  3VYY  (X-ray  2.90A  ) 
DBSNP rs1049264 
Subcellular location [CC]Nucleus {ECO:0000269|PubMed:10198287, ECO:0000269|PubMed:10207077, ECO:0000269|PubMed:11687588, ECO:0000269|PubMed:16375861, ECO:0000269|PubMed:17303075, ECO:0000269|PubMed:9162007}. Nucleus, nucleoplasm {ECO:0000269|PubMed:28221134}. Nucleus, nucleolus {ECO:0000269|PubMed:12429849}. Cytoplasm {ECO:0000269|PubMed:10198287, ECO:0000269|PubMed:10207077, ECO:0000269|PubMed:16375861, ECO:0000269|PubMed:17289661, ECO:0000269|PubMed:19029303, ECO:0000269|PubMed:20696886, ECO:0000269|PubMed:8690889, ECO:0000269|PubMed:9162007}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843, ECO:0000269|PubMed:17498979}. Note=Nucleoplasmic shuttling protein (PubMed:10198287, PubMed:16375861, PubMed:10207077, PubMed:9162007). Its nuclear import involves the nucleocytoplasmic transport receptor Importin alpha/Importin beta receptor pathway in a Ran-dependent manner (PubMed:16375861). In interphase, localizes in nuclear stress granules and at perichromatin fibrils and in cytoplasmic ribonucleoprotein granules (PubMed:10198287). Colocalizes with WRN and H2AX at centrosomes in a microtubule-dependent manner following DNA damaging agent treatment (PubMed:17498979). Excluded from the mitotic nucleus as early as prophase and re-entered the nucleus at telophase (PubMed:10198287). Recruited in diffuse and discrete intranuclear foci (GLFG-body) in a NUP98-dependent manner (PubMed:28221134). Colocalizes with SP7 in the nucleus (PubMed:17303075). Colocalizes with ACTB at nuclear actin filaments inside the nucleus or at the nuclear pore (PubMed:11687588). Colocalizes with HNRNPC at nuclear ribonucleoprotein complex proteins in the nucleus (PubMed:11687588). Localized in cytoplasmic mRNP granules containing untranslated mRNAs (PubMed:17289661). {ECO:0000269|PubMed:10198287, ECO:0000269|PubMed:10207077, ECO:0000269|PubMed:11687588, ECO:0000269|PubMed:16375861, ECO:0000269|PubMed:17289661, ECO:0000269|PubMed:17303075, ECO:0000269|PubMed:17498979, ECO:0000269|PubMed:28221134, ECO:0000269|PubMed:9162007}.
Mouse PG classificationNA
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