| Gene Information | |
|---|---|
| Gene Name | DHX8 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1220 |
| Protein Names | ATP-dependent RNA helicase DHX8 (EC 3.6.4.13) (DEAH box protein 8) (RNA helicase HRH1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000067596 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q14562 |
| Gene Card | DHX8 |
| Uniprot ID | Q14562 |
| Pfam | PF04408; PF00271; PF07717; PF00575 |
| In ASD | no |
| Allosteric Prediction | no (-0.800634618) |
| Ortholog in Animals | Alpaca_ DHX8 ( ortholog_one2one ) Dog_ DHX8 ( ortholog_one2one ) GuineaPig_ DHX8 ( ortholog_one2one ) Macaque_ DHX8 ( ortholog_one2one ) Mouse_ Dhx8 ( ortholog_one2one ) Pig_ DHX8 ( ortholog_one2one ) Rat_ Dhx8 ( ortholog_one2one ) Rabbit_ DHX8 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | YTHDC2, DHX40, DHX34, DHX32, HELB, DHX57, DHX30, DHX29, DHX36, DHX15, DHX35, DHX9, DHX38, DQX1, DHX16, DHX33, TDRD9, DHX37 |
| Tissue | NA |
| Tissue Specificity | Expressed in skin, cervix and nerve. Also expressed in the brain. {ECO:0000269|PubMed:31256877}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2EQS (NMR - ) 3I4U (X-ray 2.10A ) 5MQF (EM 5.90A ) 5XJC (EM 3.60A ) 6HYS (X-ray 2.60A ) 6HYT (X-ray 2.33A ) 6HYU (X-ray 3.22A ) 6ICZ (EM 3.00A ) 6QDV (EM 3.30A ) 7W59 (EM 3.60A ) 7W5A (EM 3.60A ) 7W5B (EM 4.30A ) |
| DBSNP | rs34285079 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:28062851, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770}. |
| Mouse PG classification | NA |
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