| Gene Information | |
|---|---|
| Gene Name | MMP21 |
| Organism | Homo sapiens (Human) |
| Gene Length | 569 |
| Protein Names | Matrix metalloproteinase-21 (MMP-21) (EC 3.4.24.-) |
| Target Name | matrix metalloproteinase-21 |
| Target Type | NA |
| Gene Age | 950 ( ENSG00000154485 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q8N119 |
| Gene Card | MMP21 |
| Uniprot ID | Q8N119 |
| Pfam | PF00045; PF00413; PF01471 |
| In ASD | no |
| Allosteric Prediction | no (-0.968816366) |
| Ortholog in Animals | Alpaca_ MMP21 ( ortholog_one2one ) Dog_ MMP21 ( ortholog_one2one ) GuineaPig_ MMP21 ( ortholog_one2one ) Macaque_ MMP21 ( ortholog_one2one ) Mouse_ Mmp21 ( ortholog_one2one ) Rat_ Mmp21 ( ortholog_one2one ) Rabbit_ MMP21 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | MMP24, MMP16, MMP14, MMP2, MMP1, MMP19, MMP23B, MMP10, MMP9, MMP12, MMP15, MMP27, MMP17, MMP25, MMP28, MMP13, MMP7, MMP20, MMP26, HPX, MMP8, MMP3, MMP11 |
| Tissue | NA |
| Tissue Specificity | Identified in fetal brain, kidney and liver. In adult tissues found primarily in ovary, kidney, liver, lung, placenta, brain and peripheral blood leukocytes. Expressed as well in various cancer cell lines. {ECO:0000269|PubMed:12490321, ECO:0000269|PubMed:12617721}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs746379956 rs28381282 rs28381284 rs10901425 rs145789868 rs781127723 rs34811493 rs1434829861 rs747668147 rs17173746 rs773125891 rs28381302 rs946722250 rs17153524 rs150320323 rs28381319 |
| Subcellular location [CC] | Secreted {ECO:0000305}. |
| Mouse PG classification | HPG |
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