| Gene Information | |
|---|---|
| Gene Name | DHTKD1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 919 |
| Protein Names | 2-oxoadipate dehydrogenase complex component E1 (E1a) (OADC-E1) (OADH-E1) (EC 1.2.4.-) (2-oxoadipate dehydrogenase, mitochondrial) (Alpha-ketoadipate dehydrogenase) (Alpha-KADH-E1) (Dehydrogenase E1 and transketolase domain-containing protein 1) (Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1064 ( ENSG00000181192 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q96HY7 |
| Gene Card | DHTKD1 |
| Uniprot ID | Q96HY7 |
| Pfam | PF00676; PF16870; PF02779 |
| In ASD | no |
| Allosteric Prediction | yes (0.219047638) |
| Ortholog in Animals | Alpaca_ DHTKD1 ( ortholog_one2one ) Dog_ DHTKD1 ( ortholog_one2one ) GuineaPig_ DHTKD1 ( ortholog_one2one ) Macaque_ SEC61A2 ( ortholog_one2one ) Mouse_ Dhtkd1 ( ortholog_one2one ) Pig_ DHTKD1 ( ortholog_one2one ) Rat_ Dhtkd1 ( ortholog_one2one ) Rabbit_ DHTKD1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | OGDH, OGDHL |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 5RVW (X-ray 1.61A ) 5RVX (X-ray 1.66A ) 5RVY (X-ray 1.61A ) 5RVZ (X-ray 1.98A ) 5RW0 (X-ray 1.67A ) 5RW1 (X-ray 1.52A ) 6SY1 (X-ray 1.87A ) 6U3J (X-ray 2.25A ) |
| DBSNP | rs1279138 rs3740015 rs200922071 rs17849603 rs34716552 rs142068634 rs2062988 rs200788729 rs117225135 rs200355418 |
| Subcellular location [CC] | Mitochondrion {ECO:0000269|PubMed:23141294}. |
| Mouse PG classification | NA |
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