| Gene Information | |
|---|---|
| Gene Name | CSF1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 554 |
| Protein Names | Macrophage colony-stimulating factor 1 (CSF-1) (M-CSF) (MCSF) (Lanimostim) [Cleaved into: Processed macrophage colony-stimulating factor 1] |
| Target Name | macrophage colony-stimulating factor 1 |
| Target Type | Clinical trial target |
| Gene Age | 544 ( ENSG00000184371 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P09603 |
| Gene Card | CSF1 |
| Uniprot ID | P09603 |
| Pfam | PF05337 |
| In ASD | yes |
| Allosteric Prediction | yes (0.658787549) |
| Ortholog in Animals | Alpaca_ CSF1 ( ortholog_one2one ) Dog_ CSF1 ( ortholog_one2one ) Macaque_ CSF1 ( ortholog_one2one ) Mouse_ Csf1 ( ortholog_one2one ) Pig_ CSF1 ( ortholog_one2one ) Rat_ Csf1 ( ortholog_one2one ) Rabbit_ CSF1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.005990(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1HMC (X-ray 2.50A ) 3UEZ (X-ray 3.41A ) 3UF2 (X-ray 2.75A ) 4ADF (X-ray 4.40A ) 4FA8 (X-ray 2.20A ) 4WRL (X-ray 2.80A ) 4WRM (X-ray 6.85A ) 5LXF (X-ray 2.00A ) |
| DBSNP | rs12565736 rs1058885 rs2229165 rs333971 rs12721516 rs2229167 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:1531650, ECO:0000269|PubMed:3264877}; Single-pass type I membrane protein {ECO:0000269|PubMed:1531650, ECO:0000269|PubMed:3264877}.; [Processed macrophage colony-stimulating factor 1]: Secreted, extracellular space. |
| Mouse PG classification | NA |
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