| Gene Information | |
|---|---|
| Gene Name | DHRS3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 302 |
| Protein Names | Short-chain dehydrogenase/reductase 3 (EC 1.1.1.300) (DD83.1) (Retinal short-chain dehydrogenase/reductase 1) (retSDR1) (Retinol dehydrogenase 17) (Short chain dehydrogenase/reductase family 16C member 1) |
| Target Name | short-chain dehydrogenase/reductase 3 |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000162496 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | O75911 |
| Gene Card | DHRS3 |
| Uniprot ID | O75911 |
| Pfam | PF00106 |
| In ASD | no |
| Allosteric Prediction | no (-0.030727169) |
| Ortholog in Animals | Alpaca_ DHRS3 ( ortholog_one2one ) Dog_ DHRS3 ( ortholog_one2one ) GuineaPig_ DHRS3 ( ortholog_one2one ) Macaque_ DHRS3 ( ortholog_one2one ) Mouse_ Dhrs3 ( ortholog_one2one ) Pig_ DHRS3 ( ortholog_one2one ) Rat_ Dhrs3 ( ortholog_one2one ) |
| Ohnologs | RDH10 |
| Paralogs | SDR9C7, HSD17B14, HSD17B7, HSD11B2, DHRS12, RDH12, HSDL1, HSD17B4, DHRS9, RDH11, RDH16, HSD17B8, HSD17B11, BDH1, WWOX, HSD17B2, RDH5, HSD17B13, HSD17B12, SDR16C5, HSD17B1, RDH10, HSD17B10, HSD17B3, HSD17B6 |
| Tissue | NA |
| Tissue Specificity | Widely expressed with highest levels found in heart, placenta, lung, liver, kidney, pancreas, thyroid, testis, stomach, trachea and spinal cord. Lower levels found in skeletal muscle, intestine and lymph node. No expression detected in brain. In the retina, expressed in cone but not rod outer segments. {ECO:0000269|PubMed:11861404, ECO:0000269|PubMed:9705317}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs1128251 |
| Subcellular location [CC] | Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. |
| Mouse PG classification | NA |
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