| Gene Information | |
|---|---|
| Gene Name | DHRS2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 280 |
| Protein Names | Dehydrogenase/reductase SDR family member 2, mitochondrial (EC 1.1.1.-) (Dicarbonyl reductase HEP27) (Protein D) (Short chain dehydrogenase/reductase family 25C member 1) (Protein SDR25C1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000100867 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q13268 |
| Gene Card | DHRS2 |
| Uniprot ID | Q13268 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | no (-0.182529662) |
| Ortholog in Animals | Alpaca_ DHRS2 ( ortholog_one2one ) Dog_ DHRS2 ( ortholog_one2one ) Macaque_ DHRS2 ( ortholog_one2one ) Mouse_ Dhrs2 ( ortholog_one2one ) Rat_ Dhrs2 ( ortholog_one2one ) Rabbit_ DHRS2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | DHRS7C, DHRS7, HSD11B1, RDH8, CBR3, HSDL2, DHRS7B, HSD11B1L, DHRS4L2, DHRS4, DHRS11, CBR1, DHRS1 |
| Tissue | urinary.bladder |
| Tissue Specificity | Widely expressed, with highest levels in liver and kidney, followed by heart, spleen, skeletal muscle and placenta. In hemopoietic cells, expressed in dendritic cells, but not in monocytes, macrophages, granulocytes, nor in B and T lymphocytes. {ECO:0000269|PubMed:11944995}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs148991912 |
| Subcellular location [CC] | Mitochondrion matrix. Nucleus. Note=A minor fraction of the protein is translocated from the mitochondria to the nucleus, after cleavage of the targeting signal. |
| Mouse PG classification | NA |
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