| Gene Information | |
|---|---|
| Gene Name | PRO2521 |
| Organism | Homo sapiens (Human) |
| Gene Length | 416 |
| Protein Names | Gasdermin-B (Gasdermin-like protein) [Cleaved into: Gasdermin-B, N-terminal (GSDMB-NT) (p30); Gasdermin-B, C-terminal (GSDMB-CT) (p16)] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q8TAX9 |
| Gene Card | GSDMB |
| Uniprot ID | Q8TAX9 |
| Pfam | PF04598; PF17708 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | In the gastrointestinal tract, expressed in proliferating cells, including in the basal cell layer of esophagus and in isthmus/neck of stomach. {ECO:0000269|PubMed:19051310}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 5TIB (X-ray 2.60A ) 5TJ2 (X-ray 2.80A ) 5TJ4 (X-ray 3.50A ) |
| DBSNP | rs12450091 rs4619433 rs2305479 rs2305480 rs16965388 |
| Subcellular location [CC] | [Gasdermin-B]: Cytoplasm {ECO:0000269|PubMed:18038310}. Note=Vesicular localization in the apical region of gastric chief cells and colonic surface mucous cells, and the basal region of neuroendocrine cells. {ECO:0000269|PubMed:18038310}.; [Gasdermin-B, N-terminal]: Cell membrane {ECO:0000250|UniProtKB:Q5Y4Y6}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q5Y4Y6}. |
| Mouse PG classification | NA |
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